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首页> 外文期刊>Natural product communications >Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella
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Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

机译：Baccharis uncinella的抗锥虫酚类衍生物

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Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O- dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC_(50)) values of 52, 81 and 56 μg/mL, respectively, while the chlorogenic acid mixture showed an IC_(50) value of 61 μg/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC_(50)) ranging from 33.82 to 129.1 μg/mL while the chlorogenic acids did not display cytotoxicity (CC_(50) >150 μg/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
机译：Baccharis uncinella C.DC空中部分的EtOH提取物的生物测定指导分级分离。 （菊科）鉴定出两种肉桂酸衍生物（咖啡酸和阿魏酸），两种黄酮（hispidulin和果胶苷）以及三种绿原酸（3,4-，3,5-和4,5-O-二咖啡酰奎尼酸）的混合物酸），从而显示出体外的抗锥虫活性。果胶苷，组蛋白和咖啡酸显示出对克氏锥虫的拟鞭毛体的活性，分别表现出50％的抑制浓度（IC_（50））值为52、81和56μg/ mL，而绿原酸混合物显示的IC_（50）值61微克/毫升。评估了类黄酮和肉桂酸衍生物对NCTC细胞的细胞毒性，得出50％的细胞毒性浓度（CC_（50））为33.82至129.1μg/ mL，而绿原酸不显示出细胞毒性（CC_（50）> 150μg / mL）。这是来自Uncinella B. uncinella化合物的抗锥虫活性的首次报道。

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