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Molecular evolution meets the genomics revolution [Review]

机译:分子进化遇到了基因组学革命[综述]

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Changes in technology in the past decade have had such an impact on the way that molecular evolution research is done that it is difficult now to imagine working in a world without genomics or the Internet. In 1992, GenBank was less than a hundredth of its current size and was updated every three months on a huge spool of tape. Homology searches took 30 minutes and rarely found a hit. Now it is difficult to find sequences with only a few homologs to use as examples for teaching bioinformatics. For molecular evolution researchers, the genomics revolution has showered us with raw data and the information revolution has given us the wherewithal to analyze it. In broad terms, the most significant outcome from these changes has been our newfound ability to examine the evolution of genomes as a whole, enabling us to infer genome-wide evolutionary patterns and to identify subsets of genes whose evolution has been in some way atypical. [References: 214]
机译:在过去的十年中,技术的变化对分子进化研究的进行方式产生了巨大的影响,以至于现在很难想象在没有基因组学或互联网的情况下如何工作。 1992年,GenBank不到当前规模的百分之一,并且每三个月更新一次巨大的磁带卷轴。同源性搜索花费了30分钟,很少发现成功。现在很难找到只有几个同源物的序列作为生物信息学教学的例子。对于分子进化研究人员而言,基因组学革命给我们带来了原始数据,而信息革命给了我们进行分析的资金。从广义上讲,这些变化最显着的结果是我们新发现的能力,可以检查整个基因组的整体进化,从而使我们能够推断出全基因组的进化模式,并鉴定出进化以某种方式是非典型的基因子集。 [参考:214]

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