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首页> 外文期刊>Cancer science. >Recent advances in the molecular pathology of soft tissue sarcoma: Implications for diagnosis, patient prognosis, and molecular target therapy in the future
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Recent advances in the molecular pathology of soft tissue sarcoma: Implications for diagnosis, patient prognosis, and molecular target therapy in the future

机译：软组织肉瘤分子病理学的最新进展：对未来诊断，患者预后和分子靶标治疗的意义

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Soft tissue sarcomas are relatively rare malignant neoplasms compared with carcinomas and other neoplasms, and they constitute less than 1% of all cancers. STS are composed of many histological subtypes, such as pleomorphic undifferentiated sarcoma or malignant fibrous histiocytoma, leiomayosarcoma, and liposarcoma. In addition to their wide variety of subtypes, it is often difficult to make an accurate histological diagnosis because certain kinds of STS share similar morphological features. However, it is important to make a definitive diagnosis so that adequate therapy can be administered in each case. Recently, several reciprocal chromosomal translocations and fusion transcripts have been proven to be characteristic of particular histological types (Table 1; Fig. 1). The detection of these fusion transcripts is useful for the differential diagnosis of histologically peculiar cases#
机译：与癌和其他肿瘤相比，软组织肉瘤是相对罕见的恶性肿瘤，占所有癌症的不到1％。 STS由许多组织学亚型组成，例如多形性未分化肉瘤或恶性纤维组织细胞瘤，平滑肌肉肉瘤和脂肪肉瘤。除了它们的多种亚型外，由于某些种类的STS具有相似的形态特征，通常也很难进行准确的组织学诊断。但是，重要的是要进行明确的诊断，以便可以在每种情况下进行适当的治疗。最近，已证明几种相互的染色体易位和融合转录本是特定组织学类型的特征（表1;图1）。这些融合转录本的检测对于组织学特殊病例的鉴别诊断很有用＃

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