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首页> 外文期刊>Nature immunology >Priming of naive T cells inside tumors leads to eradication of established tumors
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Priming of naive T cells inside tumors leads to eradication of established tumors

机译：启动肿瘤内部的幼稚T细胞导致根除已建立的肿瘤

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The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-receptor and T cell-expressed herpes viral entry mediator (HVEM). Here we show that forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and expression of adhesion molecules. Activation of these infiltrating T cells, possibly through HVEM, leads to the rejection of established, highly progressive tumors at local and distal sites. Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy.
机译：由非抗原性基质细胞组成的肿瘤屏障可能导致肿瘤排斥反应失败。肿瘤坏死因子超家族成员LIGHT（也称为TNFSF-14）是基质细胞表达的淋巴毒素受体和T细胞表达的疱疹病毒进入介体（HVEM）的配体。在这里，我们表明在肿瘤环境中强制表达LIGHT会诱导大量的幼稚T淋巴细胞浸润，这与趋化因子产生和粘附分子表达的上调相关。这些浸润性T细胞的激活可能通过HVEM激活，导致局部和远端部位已建立的高度进展的肿瘤被排斥。我们的研究表明，靶向肿瘤屏障可能是癌症免疫疗法的有效策略。

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