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首页> 外文期刊>Nature immunology >Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella
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Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella

机译：溶血磷脂感测触发致病性沙门氏菌分泌鞭毛蛋白

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摘要

Flagellin induces inflammatory and innate immune responses through activation of Toll-like receptor 5. Here we show that proinflammatory monomeric flagellin produced by salmonella during infection of intestinal epithelial cells was not derived from polymeric bacterial cell wall-associated flagellum but instead was synthesized and secreted de novo by the bacterium after direct sensing of host-produced lysophospholipids. Inhibition of lysophospholipid biosynthesis in intestinal epithelial cells reduced flagellin production and release from salmonella. Lysophospholipids induced a cAMP-dependent signaling pathway in salmonella that resulted in production and secretion of active flagellin. The induction of Toll-like receptor ligand synthesis and secretion by a host signal represents a previously unknown regulatory mechanism for inflammation and innate immunity during infection with a bacterial pathogen.
机译：鞭毛蛋白通过激活Toll样受体5诱导炎性和先天性免疫反应。在这里，我们显示沙门氏菌在肠上皮细胞感染过程中产生的促炎性单体鞭毛蛋白并非源自聚合细菌细胞壁相关鞭毛，而是合成并分泌的直接感测宿主产生的溶血磷脂后，细菌从头开始。肠上皮细胞中溶血磷脂生物合成的抑制减少鞭毛蛋白的产生和沙门氏菌的释放。溶血磷脂诱导沙门氏菌中cAMP依赖的信号传导途径，导致活性鞭毛蛋白的产生和分泌。宿主信号诱导Toll样受体配体合成和分泌代表了细菌病原体感染期间炎症和先天免疫的未知调节机制。

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