Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

Jagan R Muppidi; Richard M Siegel

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Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

机译：Fas（CD95）的非配体依赖性重新分布到脂质筏中，介导克隆型T细胞死亡

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Clonotypic elimination of activated T cells through Fas-Fas ligand (CD95-CD95L) interactions is one mechanism of peripheral self-tolerance. T cell receptor (TCR) stimuli trigger FasL synthesis but also sensitize activated T cells to Fas-mediated apoptosis through an unknown mechanism. Here we show that TCR restimulation of activated human CD4~+ T cells resulted in Fas translocation into lipid raft microdomains before binding FasL, rendering these cells sensitive to apoptosis after stimulation with bivalent antibody or FasL. Disruption of lipid rafts reduced sensitivity to Fas-mediated apoptosis after TCR restimulation. Thus, the redistribution of Fas and other tumor necrosis factor family receptors into and out of lipid rafts may dynamically regulate the efficiency and outcomes of signaling by these receptors.

机译：通过Fas-Fas配体（CD95-CD95L）相互作用对活化的T细胞进行克隆型消除是外周自我耐受的机制之一。 T细胞受体（TCR）刺激触发FasL合成，但也通过未知机制使活化的T细胞对Fas介导的细胞凋亡敏感。在这里，我们显示激活的人CD4〜+ T细胞的TCR重新刺激导致Fas在结合FasL之前易位到脂质筏微结构域，使这些细胞对二价抗体或FasL刺激后对凋亡敏感。脂质筏的破坏降低了TCR再刺激后对Fas介导的细胞凋亡的敏感性。因此，Fas和其他肿瘤坏死因子家族受体在脂质筏中的重新分布可能动态调节这些受体的信号传导效率和结果。

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《Nature immunology》 |2004年第2期|共8页
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Jagan R Muppidi; Richard M Siegel;
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1. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death [J] . Jagan R Muppidi, Richard M Siegel Nature immunology . 2004,第2期

机译：Fas（CD95）的非配体依赖性重新分布到脂质筏中，介导克隆型T细胞死亡
2. Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines [J] . Kenneth H. Shain, Terry H. Landowski, William S. Dalton The journal of immunology . 2002,第5期

机译：粘附介导的c-Fas相关的死亡域样IL-1转换酶样抑制蛋白长的细胞内再分配赋予抗CD95诱导的造血癌细胞系凋亡。
3. Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines [J] . Kenneth H. Shain, Terry H. Landowski, William S. Dalton The journal of immunology . 2002,第5期

机译：粘附介导的c-Fas相关的死亡域样IL-1转换酶样抑制蛋白长的细胞内再分配赋予抗CD95诱导的造血癌细胞系凋亡。
4. CD95-mediated apoptosis: immune mission to death [C] . P. H. KRAMME Falk Symposium . 2005

机译：CD95介导的细胞凋亡：免疫使命死亡
5. Roles of cellular FLICE-inhibitory protein (c-FLIP) and PI3K/Akt in Fas (CD95)-induced NF-kappaB activation and apoptosis through death effector domains. [D] . Lu, Bin. 2005

机译：细胞FLICE抑制蛋白（c-FLIP）和PI3K / Akt在Fas（CD95）诱导的NF-κB活化和细胞凋亡中通过死亡效应域的作用。
6. Molecular Basis of Cytotoxicity of Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) in EBV Latency III B Cells: LMP1 Induces Type II Ligand-Independent Autoactivation of CD95/Fas with Caspase 8-Mediated Apoptosis [O] . Christophe Le Clorennec, Tan-Sothéa Ouk, Ibtissam Youlyouz-Marfak, 2008

机译：EBV潜伏期III B细胞中爱泼斯坦-巴尔病毒（EBV）潜在膜蛋白1（LMP1）的细胞毒性的分子基础：LMP1诱导Caspase 8介导的凋亡的CD95 / Fas的II型配体非依赖性自激活。
7. Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines [O] . Kenneth H. Shain, Terry H. Landowski, William S. Dalton 2002

机译：粘附介导的C-FAS相关死亡域样IL-1转化酶样抑制蛋白的抗性促进血管生成癌细胞系中CD95诱导的凋亡的诱导酶的细胞内再分分配

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

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