Mal-function of TLRs by SOCS

Kobayashi T; Takaesu G; Yoshimura A

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Mal-function of TLRs by SOCS

机译：SOCS对TLR的故障

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摘要

Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1-mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.

机译：细胞因子信号转导抑制因子1与Toll样受体信号转导的负调控有关。该机制似乎是细胞因子信号转导因子1介导的Mal降解的抑制因子，这是Toll样受体信号转导所必需的。

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来源
《Nature immunology》 |2006年第2期|共2页
作者
Kobayashi T; Takaesu G; Yoshimura A;
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正文语种 eng
中图分类基础医学;
关键词
NEGATIVE REGULATION; PHOSPHORYLATION; ACTIVATION; KINASE;

机译：负调节;磷酸化;活化;激酶;

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专利

1. Mal-function of TLRs by SOCS [J] . Kobayashi T, Takaesu G, Yoshimura A Nature immunology . 2006,第2期

机译：SOCS对TLR的故障
2. Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS Pathway [J] . Xiao-ling Li, Bo Zhang, Wei Liu, Frontiers in Neuropharmacology . 2020,第a期

机译：雷帕霉素通过调解TAM-TLRS-SOC途径，减轻了实验性自身免疫脑脊髓炎（EAE）中多发性硬化症的症状
3. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice [J] . Paul Amber M., Acharya Dhiraj, Le Linda, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2016,第11期

机译：TLR8偶联SOCS-1并抑制TLR7介导的抗病毒免疫，加剧了小鼠的西尼罗河病毒感染。
4. Induction of Toll-like receptor (TLR) 2 and Myeloid88-dependent TLR-Signaling Response to Aeromonas Hydrophila Infections in Gouramy (Osphronemus Gouramy) [C] . D Kusumawaty, S Suhandono, A Pancoro Annual Applied Science and Engineering Conference . 2017

机译：诱导Toll样受体（TLR）2和Myeloid88依赖性TLR信号传导反应对植物（Quapromus植物）的AeroMonas疏水液感染
5. Novel Insights into TLR4:TLR3 Crosstalk in Response to TLR4 Specific Ultrapure Lipopolysaccharide (LPS) from Highly Pathogenic Escherichia coli 0111:B4 in Murine Microglia [D] . LaBier, Brett Arthur. 2021

机译：对TLR4：TLR3串扰的新颖见解响应于TLR4特异性超纯多糖（LPS）来自高致病性大肠杆菌0111：B4在鼠髓中的B4
6. Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS Pathway [O] . Xiao-ling Li, Bo Zhang, Wei Liu, 2020

机译：雷帕霉素通过调解TAM-TLRS-SOCS途径来减轻实验性自身免疫脑脊髓炎（EAE）中多发性硬化症的症状
7. Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS Pathway [O] . Xiao-ling Li, Bo Zhang, Wei Liu, 2020

机译：雷帕霉素通过调解TAM-TLRS-SOCS途径来减轻实验性自身免疫脑脊髓炎（EAE）中多发性硬化症的症状

Mal-function of TLRs by SOCS

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