Vagaries of conditional gene targeting

Schmidt-Supprian M; Rajewsky K

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Vagaries of conditional gene targeting

机译：条件基因靶向的变化无常

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Conditional gene targeting based on excision or inversion of loxP-flanked DNA segments by Cre recombinase is a powerful technology for the analysis of gene function, but unexpected expression patterns of cre transgenes, variability of recombination efficiency depending on the target gene and potential toxicity of Cre recombinase represent serious challenges for the experimenter.

机译：基于Cre重组酶切除或反转loxP侧翼DNA片段的条件基因靶向是分析基因功能的强大技术，但是cre转基因的意想不到的表达方式，重组效率的变化取决于目标基因和Cre的潜在毒性重组酶对实验者提出了严峻的挑战。

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《Nature immunology》 |2007年第7期|共4页
作者
Schmidt-Supprian M; Rajewsky K;
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正文语种 eng
中图分类基础医学;
关键词
CRE RECOMBINASE; CELL-DEVELOPMENT; MAMMALIAN-CELLS; TRANSGENIC MICE; B-LYMPHOCYTES; TOXICITY; MAINTENANCE; EXPRESSION; GENOMES;

机译：CRE重组酶;细胞发育;哺乳动物细胞;转基因小鼠;B淋巴细胞;毒性;维持性;表达;基因组;

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1. Vagaries of conditional gene targeting [J] . Schmidt-Supprian M, Rajewsky K Nature immunology . 2007,第7期

机译：条件基因靶向的变化无常
2. A useful gene cassette for conditional knock-down of essential genes by targeted promoter replacement in Mycobacteria. [J] . Pauline Texier, Michèle Coddeville, Patricia Bordes, BioTechniques . 2018,第3期

机译：一种有用的基因盒，用于靶向启动子在分枝杆菌中的靶向基因的条件倒闭。
3. The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models [J] . James C. Neil, Kathryn Gilroy, Gillian Borl, Advances in Experimental Medicine and Biology . 2017,第期

机译：Runx基因作为条件癌症：逆转录病毒靶向和小鼠模型的见解
4. Generating target/non-target images of an RSVP experiment from brain signals in by conditional generative adversarial network [C] . Yonggun Lee, Yufei Huang IEEE EMBS International Conference on Biomedical and Health Informatics . 2018

机译：通过条件生成的对抗网络从脑信号产生RSVP实验的目标/非目标图像
5. Construction of a targeting vector by recombineering and generation of Cebpd conditional knockout mice for the study of cell-type specific functions of C/EBPdelta in vivo. [D] . Sharan, Shikha. 2013

机译：通过重组和生成Cebpd条件敲除小鼠构建靶向载体，以研究体内C / EBPdelta的细胞类型特异性功能。
6. Transgenic Cotton (Gossypium hirsutum L.) to Combat Weed Vagaries: Utility of an Apical Meristem-Targeted in planta Transformation Strategy to Introgress a Modified CP4-EPSPS Gene for Glyphosate Tolerance [O] . Kesiraju Karthik, Muralimohan Nandiganti, Arulprakash Thangaraj, 2020

机译：转基因棉（Gossypium hirsutum L.）来打击杂草变幻莫测：植物在植物转化策略中的效用术语术语术语术语术语术语术语术语渗流改性CP4-EPSPS基因
7. Transgenic Cotton (Gossypium hirsutum L.) to Combat Weed Vagaries: Utility of an Apical Meristem-Targeted in planta Transformation Strategy to Introgress a Modified CP4-EPSPS Gene for Glyphosate Tolerance [O] . Kesiraju Karthik, Muralimohan Nandiganti, Arulprakash Thangaraj, 2020

机译：转基因棉（Gossypium hirsutum L.）来打击杂草变幻莫测：植物在植物转化策略中的效用，术语术语术语术语术语术语术语术语渗流改性CP4-EPSPS基因

Vagaries of conditional gene targeting

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