Natural killer cells: diversity in search of a niche

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Natural killer cells: diversity in search of a niche

机译：自然杀手细胞：多样性寻找利基

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Over the years, the enigmatic lifestyle of natural killer (NK) cells has fascinated immunologists. Elucidating the principles governing NK cell biology is a constant source of surprise, as these lymphocytes often break the rules of lymphocyte `behavior' established by their T and B cell counterparts. In this Focus issue, experts address how NK cells have secured a fundamental place in the immune system, how they `see' their targets and how they participate in and influence immune responses. We now need to understand how environmental `niches' condition the generation and function of distinct NK cell subsets in vivo. Ultimately, we can hope that unraveling the mysteries of how these atypical lymphocytes function will have an impact on human disease therapies.

机译：多年来，自然杀手（NK）细胞的神秘生活方式吸引了免疫学家。阐明控制NK细胞生物学的原理总是令人惊讶，因为这些淋巴细胞经常破坏其T细胞和B细胞对应物建立的淋巴细胞“行为”规则。在本期焦点期刊中，专家将探讨NK细胞如何在免疫系统中确保基本地位，如何“看到”其靶标以及如何参与和影响免疫反应。现在，我们需要了解环境“生态位”如何调节体内不同NK细胞亚群的产生和功能。最终，我们可以希望揭开这些非典型淋巴细胞如何发挥作用的奥秘，将对人类疾病治疗产生影响。

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《Nature immunology》 |2008年第5期|共3页
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正文语种 eng
中图分类基础医学;
关键词
CLASS-I MOLECULES; DEVELOPMENTAL PATHWAYS; INHIBITORY RECEPTORS; DENDRITIC CELLS; MISSING SELF; NK-CELLS; RECOGNITION; SPECIFICITY; TOLERANCE; SUBSETS;

机译：I类分子;发育途径;抑制受体;树突状细胞;自我缺失;NK细胞;识别;特异性;公差;子集;

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专利

1. Natural killer cells: diversity in search of a niche [J] . Di Santo JP Nature immunology . 2008,第5期

机译：自然杀手细胞：多样性寻找利基
2. Cooperative action of CD8 T lymphocytes and natural killer cells controls tumour growth under conditions of restricted T-cell receptor diversity. [J] . Shanker A, Buferne M, Schmitt Verhulst AM Immunology: An Official Journal of the British Society for Immunology . 2010,第1期

机译：CD8 T淋巴细胞和自然杀伤细胞的协同作用在限制T细胞受体多样性的条件下控制肿瘤的生长。
3. The search for the missing 'missing-self' receptor on natural killer cells. [J] . Yokoyama WM Scandinavian journal of immunology. . 2002,第3期

机译：在自然杀伤细胞上寻找缺失的“失踪自我”受体。
4. Unnatural killer cells: TRAIL-coated leukocytes that kill cancer cells in the circulation [C] . Mitchell M.J., Wayne E.C., Rana K., 2014 40th Annual Northeast Bioengineering Conference . 2014

机译：非自然杀伤细胞：TRAIL涂层的白细胞可杀死循环中的癌细胞
5. Identification and characterization of the production of chemokines by natural killer cells and investigations into the effects of these cytokines on natural killer cell biology. [D] . Bluman, Eric Michael. 1998

机译：鉴定和表征自然杀伤细胞产生的趋化因子，并研究这些细胞因子对自然杀伤细胞生物学的影响。
6. Cooperative action of CD8 T lymphocytes and natural killer cells controls tumour growth under conditions of restricted T-cell receptor diversity [O] . Anil Shanker, Michel Buferne, Anne-Marie Schmitt-Verhulst 2010

机译：CD8 T淋巴细胞和自然杀伤细胞的协同作用在有限的T细胞受体多样性条件下控制肿瘤的生长
7. Cooperative action of CD8 T lymphocytes and natural killer cells controls tumour growth under conditions of restricted T-cell receptor diversity [O] . Shanker, Anil, Buferne, Michel, Schmitt-Verhulst, Anne-Marie 2010

机译：CD8 T淋巴细胞和自然杀伤细胞的协同作用在有限的T细胞受体多样性条件下控制肿瘤的生长

Natural killer cells: diversity in search of a niche

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