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首页> 外文期刊>Nature immunology >Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.
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Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking.

机译：环境提示，树突状细胞和组织选择性淋巴细胞运输的编程。

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摘要

Lymphocytes are imprinted during activation with trafficking programs (combinations of adhesion and chemoattractant receptors) that target their migration to specific tissues and microenvironments. Cytokines contribute, but, for gut and skin, evolution has cleverly adapted external cues from food (vitamin A) and sunlight (ultraviolet-induced vitamin D3) to imprint lymphocyte homing to the small intestines and T cell migration into the epidermis. Dendritic cells are essential: they process the vitamins to their active metabolites (retinoic acid and 1,25(OH)(2)D3) for presentation with antigen to lymphocytes, and they help export environmental cues through lymphatics to draining lymph nodes, to program the trafficking and effector functions of naive T and B cells.
机译：淋巴细胞在活化过程中被印记，其靶向目标是向特定组织和微环境迁移的运输程序（粘附和化学吸引受体的组合）。细胞因子起作用，但是对于肠道和皮肤，进化巧妙地适应了来自食物（维生素A）和阳光（紫外线诱导的维生素D3）的外部线索，从而将淋巴细胞归巢到小肠并T细胞迁移到表皮。树突状细胞是必不可少的：它们将维生素加工成活性代谢物（视黄酸和1,25（OH）（2）D3），并向淋巴细胞呈递抗原，它们有助于通过淋巴管输出环境提示，排干淋巴结，进行编程天然T细胞和B细胞的运输和效应功能。

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