• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >Global changes in the nuclear positioning of genes and intra-and interdomain genomic interactions that orchestrate B cell fate
【24h】

Global changes in the nuclear positioning of genes and intra-and interdomain genomic interactions that orchestrate B cell fate

机译：基因核定位的全局变化以及协调B细胞命运的域内和域间基因组相互作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The genome is folded into domains located in compartments that are either transcriptionally inert or transcriptionally permissive. Here we used genome-wide strategies to characterize domains during B cell development. Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra-and interdomain interactions that are developmentally regulated. We identified a spectrum of genes that switched nuclear location during early B cell development. In progenitor cells, the transcriptionally inactive locus encoding early B cell factor (Ebf1) was sequestered at the nuclear lamina, which thereby preserved their multipotency. After development into the pro-B cell stage, Ebf1 and other genes switched compartments to establish new intra-and interdomain interactions associated with a B lineage-specific transcription signature.
机译：基因组被折叠成区域，这些区域位于转录惰性或转录允许的区室中。在这里，我们使用了全基因组策略来表征B细胞发育过程中的结构域。结构相互作用矩阵分析表明，结构蛋白CTCF的占据主要与域内相互作用有关，而由组蛋白乙酰转移酶p300或转录因子E2A或PU.1结合的位点与受发育调控的域内和域间相互作用有关。我们鉴定了在早期B细胞发育过程中切换核位置的一系列基因。在祖细胞中，编码早期B细胞因子（Ebf1）的无转录活性的基因座被隔离在核层中，从而保留了它们的多能性。在发展到亲B细胞阶段后，Ebf1和其他基因切换隔室以建立与B谱系特异性转录标记相关的新的域内和域间相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号