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Regulation of T H2 development by CXCR5 + dendritic cells and lymphotoxin-expressing B cells

机译：CXCR5 +树突状细胞和表达淋巴毒素的B细胞对T H2发育的调节

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Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7 + naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4 + T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T H2 cells), which suggests that T H2 differentiation can initiate outside the T cell zone.
机译：尽管表达趋化因子受体CCR7和CCR7 +幼稚T细胞的带有抗原的树突状细胞（DC）在淋巴结的T细胞区之间发生同源碰撞，但尚不清楚DC和T细胞在T细胞中是否共定位产生效应细胞需要一定的面积​​。在这里，我们发现感染肠道线虫后，带有抗原的DC和CD4 + T细胞通过依赖于趋化因子CXCL13，B细胞和淋巴毒素的机制上调趋化因子受体CXCR5并一起位于T细胞区外。值得注意的是，表达淋巴毒素的B细胞，表达CXCR5的DC和T细胞以及CXCL13对于产生白介素4（IL-4）的2型辅助T细胞（T H2细胞）的发育也是必需的，这表明T H2的分化可以在T细胞区域外启动

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