IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8 + T cell responses to influenza A virus

PangI.K.; IchinoheT.; IwasakiA.

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IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8 + T cell responses to influenza A virus

机译：树突状细胞中的IL-1R信号取代模式识别受体，促进CD8 + T细胞对甲型流感病毒的反应

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Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8 + T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8 + T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8 + T cells during infection with a live virus.

机译：对疫苗的免疫反应需要通过树突状细胞（DC）上的模式识别受体（PRR）直接识别病原体相关分子模式（PAMP）。与疫苗接种不同，活病原体的感染通常会损害DC功能，并对宿主造成额外的损害。在这里，我们发现感染活甲型流感病毒后，通过白介素1受体（IL-1R）进行信号传导对于CD8 + T细胞的生产性启动是必需的，而通过PRR TLR7和RIG-I则不需要。由IL-1反式激活的DC既需要又足以产生病毒特异性CD8 + T细胞免疫力。我们的数据表明，在活病毒感染期间，旁观者细胞因子在引发CD8 + T细胞方面起着关键作用。

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《Nature immunology》 |2013年第3期|共8页
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PangI.K.; IchinoheT.; IwasakiA.;
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正文语种 eng
中图分类医学免疫学;
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1. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8 + T cell responses to influenza A virus [J] . PangI.K., IchinoheT., IwasakiA. Nature immunology . 2013,第3期

机译：树突状细胞中的IL-1R信号取代模式识别受体，促进CD8 + T细胞对甲型流感病毒的反应
2. CD8+ T Cell Responses following Replication-Defective Adenovirus Serotype 5 Immunization Are Dependent on CD11c+ Dendritic Cells but Show Redundancy in Their Requirement of TLR and Nucleotide-Binding Oligomerization Domain-Like Receptor Signaling [J] . Ross W. B. Lindsay, Patricia A. Darrah, Kylie M. Quinn, The journal of immunology . 2010,第3期

机译：复制缺陷型腺病毒血清型5免疫后的CD8 + T细胞应答依赖于CD11c +树突状细胞，但在其对TLR和核苷酸结合寡聚域类似受体信号的要求中显示出冗余
3. Viral neuraminidase treatment of dendritic cells enhances antigen-specificCD8(+) T cell proliferation, but does not account for the CD4(+) T cellindependence of the CD8(+) T cell response during influenza virusinfection [J] . Oh S, Belz GT, Eichelberger MC Virology . 2001,第2期

机译：树突状细胞的病毒神经氨酸酶处理可增强抗原特异性CD8（+）T细胞增殖，但不能解释流感病毒感染过程中CD8（+）T细胞反应的CD4（+）T细胞依赖性
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. Plasmacytoid and respiratory dendritic cells control the magnitude of the virus-specific CD8 T cell response to lethal dose influenza virus infections. [D] . Langlois, Ryan Andrew. 2010

机译：浆细胞样细胞和呼吸道树突状细胞控制着对致命剂量流感病毒感染的病毒特异性CD8 T细胞反应的强度。
6. IL-1R signaling in dendritic cells replaces pattern recognition receptors to promote CD8+ T cell responses to influenza A virus [O] . Iris K. Pang, Takeshi Ichinohe, Akiko Iwasaki -1

机译：树突状细胞中的IL-1R信号传导替代模式识别受体以促进CD8 + T细胞对流感病毒的反应
7. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus [O] . Iris K Pang, Takeshi Ichinohe, Akiko Iwasaki 2013

机译：树突状细胞中的IL-1R信号传导在促进对流感病毒的CD8 + T细胞应答促进模式识别受体

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8 + T cell responses to influenza A virus

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