Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

SatpathyA.T.; Brise?oC.G.; LeeJ.S.; NgD.; ManieriN.A.; KcW.; WuX.; ThomasS.R.; LeeW.-L.; TurkozM.; McDonaldK.G.; MeredithM.M.; SongC.; GuidosC.J.; NewberryR.D.; OuyangW.; MurphyT.L.; StappenbeckT.S.; GommermanJ.L.; NussenzweigM.C.; ColonnaM.; KopanR.; MurphyK.M.

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Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

机译：Notch2依赖型经典树突状细胞协调肠道免疫对附着和暴露的细菌病原体的作用

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Defense against attaching-and-effacing bacteria requires the sequential generation of interleukin 23 (IL-23) and IL-22 to induce protective mucosal responses. Although CD4+ and NKp46+ innate lymphoid cells (ILCs) are the critical source of IL-22 during infection, the precise source of IL-23 is unclear. We used genetic techniques to deplete mice of specific subsets of classical dendritic cells (cDCs) and analyzed immunity to the attaching-and-effacing pathogen Citrobacter rodentium. We found that the signaling receptor Notch2 controlled the terminal stage of cDC differentiation. Notch2-dependent intestinal CD11b+ cDCs were an obligate source of IL-23 required for survival after infection with C. rodentium, but CD103 + cDCs dependent on the transcription factor Batf3 were not. Our results demonstrate a nonredundant function for CD11b+ cDCs in the response to pathogens in vivo.

机译：防御附着细菌和细菌需要依次生成白介素23（IL-23）和IL-22，以诱导保护性粘膜反应。尽管CD4 +和NKp46 +先天性淋巴样细胞（ILC）是感染期间IL-22的关键来源，但尚不清楚IL-23的确切来源。我们使用遗传技术来消耗小鼠的经典树突状细胞（cDCs）的特定子集，并分析了对附着和消灭病原体啮齿类柠檬酸杆菌的免疫力。我们发现信号受体Notch2控制cDC分化的终端阶段。 Notch2依赖性肠道CD11b + cDCs是啮齿类念珠菌感染后存活所必需的IL-23专用来源，而依赖转录因子Batf3的CD103 + cDCs不是。我们的结果表明，CD11b + cDC在体内对病原体的反应中具有非冗余功能。

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《Nature immunology》 |2013年第9期|共12页
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SatpathyA.T.; Brise?oC.G.; LeeJ.S.; NgD.; ManieriN.A.; KcW.; WuX.; ThomasS.R.; LeeW.-L.; TurkozM.; McDonaldK.G.; MeredithM.M.; SongC.; GuidosC.J.; NewberryR.D.; OuyangW.; MurphyT.L.; StappenbeckT.S.; GommermanJ.L.; NussenzweigM.C.; ColonnaM.; KopanR.; MurphyK.M.;
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1. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens [J] . SatpathyA.T., Brise?oC.G., LeeJ.S., Nature immunology . 2013,第9期

机译：Notch2依赖型经典树突状细胞协调肠道免疫对附着和暴露的细菌病原体的作用
2. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. [J] . Wang Y, Koroleva EP, Kruglov AA, Immunity . 2010,第3期

机译：肠上皮细胞中的Lymphotoxinβ受体信号转导针对粘膜细菌感染的先天免疫应答。
3. The protein moiety of Brucella abortus outer membrane protein 16 is a new bacterial pathogen-associated molecular pattern that activates dendritic cells in vivo, induces a Th1 immune response, and is a promising self-adjuvanting vaccine against systemic and oral acquired brucellosis. [J] . Pasquevich KA, Garcia Samartino C, Coria LM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2010,第9期

机译：流产布鲁氏菌外膜蛋白16的蛋白质部分是一种新的细菌病原体相关分子模式，可在体内激活树突状细胞，诱导Th1免疫应答，并且是针对全身和口服获得性布鲁氏菌病的有希望的自佐剂疫苗。
4. Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection [C] . Andre P. Tittel, Christoph Heuser, Natalio Garbi, Else Kroener-Fresenius Symposium . 2013

机译：树突状细胞对细菌肾脏感染进行协调生先生免疫
5. Dissecting the roles of distinct dendritic cell subsets in the immune response to the intracellular bacterial pathogen, Listeria monocytogenes. [D] . Mitchell, Latoya Michelle. 2009

机译：剖析不同树突状细胞亚群在对细胞内细菌病原体单核细胞增生性李斯特菌的免疫应答中的作用。
6. Notch2-dependent classical dendritic cells orchestrate intestinal immunity against attaching and effacing bacterial pathogens [O] . Ansuman T. Satpathy, Carlos G. Briseño, Jacob S. Lee, -1

机译：Notch2依赖性经典树突状细胞协调肠道免疫力以抵抗细菌病原体的附着和脱落
7. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens [O] . Lan Kang, Xiang Zhang, Liangliang Ji, 2020

机译：结肠巨噬细胞转录因子RBP-J对细菌病原体的肠梗阻
8. Opposing Signals from Pathogen-Associated Molecular Patterns and IL-10 Are Critical for Optimal Dendritic Cell Induction of In Vivo Humoral Immunity to Streptococcus pneumoniae [R] . Colino, J., Snapper, C. M. 2003

机译：来自病原体相关分子模式和IL-10的反对信号对于肺炎链球菌的体内体液免疫的最佳树突细胞诱导是至关重要的。

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

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