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首页> 外文期刊>Nature immunology >Orchestrating the orchestrators: chemokines in control of T cell traffic.
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Orchestrating the orchestrators: chemokines in control of T cell traffic.

机译:编排协调器:控制T细胞流量的趋化因子。

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摘要

The understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors have been identified. Detailed analyses have demonstrated the function of chemokine receptors on T cell subsets, the temporal and spatial expression patterns of chemokines in vivo and the phenotypes of animals genetically deficient in one component or several components of the chemokine-chemokine receptor system. New microscopy modalities for studying the influence of chemokines on the migratory activity of T cells in the lymph node have also brought new insights. Here we review such advances with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.
机译:对趋化因子如何协调免疫细胞的运输和活性的了解已大大增加。迄今为止,已经鉴定出50多种趋化因子和20种趋化因子受体。详细的分析表明趋化因子受体在T细胞亚群上的功能,趋化因子在体内的时空表达模式以及遗传上缺乏趋化因子-趋化因子受体系统的一种或多种组分的动物的表型。研究趋化因子对淋巴结中T细胞迁移活性影响的新的显微镜方法也带来了新的见解。在这里,我们回顾这些进展,特别着重于控制T细胞亚群在稳态和炎症中的淋巴结和周围组织中的迁移。

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