The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

Itoh-NakadaiA.; HikotaR.; MutoA.; KometaniK.; Watanabe-MatsuiM.; SatoY.; KobayashiM.; NakamuraA.; MiuraY.; YanoY.; TashiroS.; SunJ.; IkawaT.; OchiaiK.; KurosakiT.; IgarashiK.

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The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

机译：转录阻遏物Bach2和Bach1通过抑制髓样程序促进B细胞发育

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Mature lymphoid cells express the transcription repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. Overexpression of Bach2 in pre-pro-B cells deficient in the transcription factor EBF1 and single-cell analysis of CLPs revealed that Bach2 and Bach1 repressed the expression of genes important for myeloid cells ('myeloid genes'). Bach2 and Bach1 bound to presumptive regulatory regions of the myeloid genes. Bach2 hi CLPs showed resistance to myeloid differentiation even when cultured under myeloid conditions. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in CLPs.

机译：成熟的淋巴样细胞表达转录抑制因子Bach2，后者可调节体液和细胞免疫。在这里，我们发现Bach2在B谱系细胞的发育中起着关键作用，该细胞从常见的淋巴祖细胞（CLP）阶段开始，以Bach1为辅助。 Bach2在缺乏转录因子EBF1的pre-pro-B细胞中的过表达和CLP的单细胞分析显示，Bach2和Bach1抑制了对髓样细胞重要的基因（“髓样基因”）的表达。 Bach2和Bach1绑定到髓样基因的假定调节区域。即使在髓样条件下培养，Bach2 hi CLP也显示出对髓样分化的抗性。我们的结果表明，Bach2与Bach1和EBF1一起发挥功能，通过抑制CLP中的髓样基因来促进B细胞发育。

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《Nature immunology》 |2014年第12期|共10页
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Itoh-NakadaiA.; HikotaR.; MutoA.; KometaniK.; Watanabe-MatsuiM.; SatoY.; KobayashiM.; NakamuraA.; MiuraY.; YanoY.; TashiroS.; SunJ.; IkawaT.; OchiaiK.; KurosakiT.; IgarashiK.;
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正文语种 eng
中图分类医学免疫学;
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1. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program [J] . Itoh-NakadaiA., HikotaR., MutoA., Nature immunology . 2014,第12期

机译：转录阻遏物Bach2和Bach1通过抑制髓样程序促进B细胞发育
2. Co-repressor SMRT and Class II Histone Deacetylases Promote Bach2 Nuclear Retention and Formation of Nuclear Foci that are Responsible for Local Transcriptional Repression [J] . Hideto Hoshino, Tomonori George Nishino, Satoshi Tashiro, Journal of Biochemistry . 2007,第5期

机译：共同阻遏物SMRT和II类组蛋白脱乙酰基酶促进负责局部转录抑制的Bach2核保留和核灶的形成。
3. The transcriptional programme of antibody class switching involves the repressor Bach2 [J] . Muto A, Tashiro S, Nakajima O, Nature . 2004,第6991期

机译：抗体类别转换的转录程序涉及阻遏物Bach2
4. (125b) Directed Evolution of Quorum-Sensing Dependent Transcriptional Repressers for Programmed Intercellular Communication [C] . Jasmine Shong American Institute of Chemical Engineers annual meeting . 2010

机译：（125b）用于编程的细胞间通信的频读依赖性转录压缩机的定向演变
5. T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells [D] . Xie, Ming. 2019

机译：T卵泡调节细胞促进生发中心反应和过敏性IgE反应，同时抑制T卵泡辅助细胞的异常分化
6. T cell fates ‘zipped up’: how the Bach2 basic leucinezipper transcriptional repressor directs T cell differentiation andfunction [O] . Martin J. Richer, Mark L. Lang, Noah S. Butler -1

机译：T细胞命运被压缩：Bach2基本亮氨酸如何拉链转录阻遏物指导T细胞分化和功能
7. Co-repressor SMRT and Class II Histone Deacetylases Promote Bach2 Nuclear Retention and Formation of Nuclear Foci that are Responsible for Local Transcriptional Repression [O] . Hideto Hoshino, Tomonori George Nishino, Satoshi Tashiro, 2007

机译：共抑制因子smRT和II类组蛋白去乙酰化酶促进Bach2核保留和形成负责局部转录抑制的核灶

The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

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