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CD43 in T cell-DC conjugate formation?

机译：CD43是否在T细胞-DC结合物中形成？

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In an analysis of antigen-independent interactions between naive T cells and dendritic cells (DCs), Revy et al. reported that higher frequencies of CD4~+ versus CD8~+ T cells developed productive interactions with DCs, as measured by calcium fluxing. To account for the observed difference between CD4~+ and CD8~+ T cell, the authors applied a panel of monoclonal antibodies (mAbs) to CD2, CD3, CD4, CD8, CD11a, CD28, CD43 and CD45 to determine whether distinct expression of cell surface molecules might be responsible. Only one mAb, 1B11, showed significant differential binding on CD8~+, but not CD4~+, T cells. This led the authors to conclude that the selective expression of a highly glycosylated, repulsive molecule, CD43, on CD8~+ T cells could explain the lower frequency of CD8~+ T cell-DC conjugates. This conclusion is based on two sets of observations: reactivity of 1B11 with the high molecular weight glycoform of CD43 arising from O-glycan branching that can occur in activated T cells and various studies that describe an anti-adhesive function of CD43.
机译：在对天然T细胞和树突状细胞（DC）之间抗原非依赖性相互作用的分析中，Revy等人。据报道，通过钙通量测量，较高频率的CD4〜+与CD8〜+ T细胞形成了与DC的生产性相互作用。为了解释观察到的CD4〜+和CD8〜+ T细胞之间的差异，作者应用了一系列针对CD2，CD3，CD4，CD8，CD11a，CD28，CD43和CD45的单克隆抗体（mAb），以确定细胞表面分子可能负责。只有一个mAb 1B11在CD8 +上显示出显着的差异结合，而在CD4 ++ T细胞上没有。这导致作者得出结论，高度糖基化的排斥分子CD43在CD8 + T细胞上的选择性表达可以解释CD8 + T细胞-DC偶联物的较低频率。该结论基于两套观察结果：1B11与活化的T细胞中可能发生的O聚糖分支产生的高分子量CD43糖型CD43的反应性，以及描述CD43的抗黏附功能的各种研究。

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