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首页> 外文期刊>Nature immunology >T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.
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T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.

机译：Nod2在促进对弓形虫的1型免疫力方面的T细胞内在作用。

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Nod2 belongs to the nucleotide-binding oligomerization domain receptor (NLR) family of proteins, which function as intracellular pathogen sensors in innate immune cells. Nod2 deficiency results in an impaired immune response to bacterial pathogens. However, how this protein promotes host defense against intracellular parasites is unknown. Here we found that Nod2(-/-) mice had less clearance of Toxoplasma gondii and lower interferon-gamma (IFN-gamma) production. Reconstitution of T cell-deficient mice with Nod2(-/-) T cells followed by T. gondii infection demonstrated a T cell-intrinsic defect. Nod2(-/-) CD4(+) T cells had poor helper T cell differentiation, which was associated with impaired production of interleukin 2 (IL-2) and nuclear accumulation of the transcription factor subunit c-Rel. Our data demonstrate a T cell-intrinsic role for Nod2 signaling that is critical for host defense against T. gondii.
机译：Nod2属于蛋白质的核苷酸结合寡聚域受体（NLR）家族，在先天免疫细胞中充当细胞内病原体传感器。 Nod2缺乏症导致对细菌病原体的免疫反应受损。然而，该蛋白如何促进宿主对细胞内寄生虫的防御还未知。在这里，我们发现Nod2（-/-）小鼠的弓形虫清除率较低，干扰素-γ（IFN-γ）产生量较低。用Nod2（-/-）T细胞重建T细胞缺陷小鼠，然后进行弓形虫感染，证明存在T细胞内在缺陷。 Nod2（-/-）CD4（+）T细胞的辅助性T细胞分化较差，这与白介素2（IL-2）的生产受损和转录因子亚基c-Rel的核积累有关。我们的数据证明了Nod2信号的T细胞内在作用，这对于抵抗弓形虫的宿主防御至关重要。

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