Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

Murai M; Turovskaya O; Kim G

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

机译：白介素10作用于调节性T细胞，以维持结肠炎小鼠中转录因子Foxp3的表达和抑制功能。

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Regulatory T cells (T(reg) cells) that express the transcription factor Foxp3 suppress the activity of other cells. Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient mice was needed to prevent the colitis induced by transferred CD4(+)CD45RB(hi) T cells. In Il10(-/-)Rag1(-/-) mice, T(reg) cells failed to maintain Foxp3 expression and regulatory activity. The loss of Foxp3 expression occurred only in recipients with colitis, which indicates that the requirement for IL-10 is manifested in the presence of inflammation. IL-10 receptor-deficient (Il10rb(-/-)) T(reg) cells also failed to maintain Foxp3 expression, which suggested that host IL-10 acted directly on the T(reg) cells. Our data indicate that IL-10 released from myeloid cells acts in a paracrine manner on T(reg) cells to maintain Foxp3 expression.

机译：表达转录因子Foxp3的调节性T细胞（T（reg）细胞）抑制其他细胞的活性。在这里，我们显示需要CD11b（+）髓样细胞在重组激活基因1缺陷（Rag1（-/-））受体小鼠中产生的白介素10（IL-10），以防止转移CD4（+）引起的结肠炎CD45RB（hi）T细胞。在Il10（-/-）Rag1（-/-）小鼠中，T（reg）细胞未能维持Foxp3表达和调节活性。 Foxp3表达的丧失仅发生在患有结肠炎的接受者中，这表明对IL-10的需求在炎症存在时得以体现。 IL-10受体缺陷（Il10rb（-/-））T（reg）细胞也无法维持Foxp3表达，这表明宿主IL-10直接作用于T（reg）细胞。我们的数据表明，从髓样细胞释放的IL-10以旁分泌的方式作用于T（reg）细胞，以维持Foxp3表达。

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《Nature immunology》 |2009年第11期|共7页
作者
Murai M; Turovskaya O; Kim G;
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1. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. [J] . Murai M, Turovskaya O, Kim G Nature immunology . 2009,第11期

机译：白介素10作用于调节性T细胞，以维持结肠炎小鼠中转录因子Foxp3的表达和抑制功能。
2. Neutralization of interleukin-10 or transforming growth factor-β decreases the percentages of CD4 +CD25 +Foxp3 + regulatory T cells in septic mice, thereby leading to an improved survival [J] . HirakiS., OnoS., TsujimotoH., Surgery . 2012,第2期

机译：中和白细胞介素10或转化生长因子-β可降低败血症小鼠CD4 + CD25 + Foxp3 +调节性T细胞的百分比，从而提高存活率
3. Type i interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice [J] . LeeS.E., LiX., KimJ.C.K., Gastroenterology . 2012,第1期

机译：I型干扰素在小鼠炎症条件下维持Foxp3表达和T调节细胞功能
4. FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors SREBP-1c and LXR in Goat Mammary Epithelial Cells [C] . Q.Y.He, J.Luo, J.Wu The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：FOXO1通过转录因子Srebp-1C和LXR抑制甾醇调节元素结合蛋白-1C（Sreb-1c）基因表达，山羊乳腺上皮细胞
5. The role of T cell-associated polarizing transcription factors in dendritic cell priming of T cells towards immunity or tolerance; role of T-bet or Foxp3 ectopic expression in dendritic cells. [D] . Lipscomb, Michael Wheeler. 2009

机译：T细胞相关的极化转录因子在T细胞树突细胞引发免疫或耐受中的作用； T-bet或Foxp3异位表达在树突状细胞中的作用
6. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis [O] . Masako Murai, Olga Turovskaya, Gisen Kim, -1

机译：白介素10只作用于调节性T细胞以保持与结肠炎小鼠转录因子Foxp3和抑制功能的表达
7. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis [O] . Masako Murai, Olga Turovskaya, Gisen Kim, 2009

机译：白细胞介素10作用于调节性T细胞，保持转录因子Foxp3的表达，并在具有结肠炎的小鼠中的抑制功能

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.

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