Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?

Rigby WF

首页> 外文期刊>Nature clinical practice. Rheumatology >Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?

【24h】

Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?

机译：药物洞察力：肿瘤坏死因子拮抗剂-被动攻击行为的不同作用机制？

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Antagonists of tumor necrosis factor (TNF) have revolutionized the treatment of selected inflammatory diseases. In rheumatology, this has been most notable for ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. Despite their specificity for TNF, these agents, which include the soluble p75 receptor etanercept and the anti-TNF antibodies adalimumab and infliximab, have demonstrated differential clinical efficacy in studies of rheumatoid arthritis; patients who do not respond to one antagonist often respond to another. Therapeutic disparity of these agents is also seen in specific diseases, most notably Crohn's disease. Differences in pharmacodynamics, pharmacokinetics and mechanisms of action, as well as disease heterogeneity, have been proposed to account for these effects. Reverse signaling by transmembrane TNF in response to anti-TNF antibodies, but not soluble receptor, might also influence the therapeutic response.

机译：肿瘤坏死因子（TNF）的拮抗剂彻底改变了某些炎性疾病的治疗方法。在风湿病学中，这对于强直性脊柱炎，银屑病关节炎和类风湿关节炎最为显着。尽管它们对TNF有特异性，但这些药物，包括可溶性p75受体依那西普和抗TNF抗体阿达木单抗和英夫利昔单抗，在类风湿关节炎的研究中已显示出不同的临床疗效。对一种拮抗剂无反应的患者通常对另一种拮抗剂有反应。这些药物的治疗差异也出现在特定疾病中，最著名的是克罗恩氏病。已提出药效学，药代动力学和作用机理以及疾病异质性方面的差异以解释这些影响。跨膜TNF响应抗TNF抗体而不是可溶性受体的反向信号也可能影响治疗反应。

著录项

来源
《Nature clinical practice. Rheumatology》 |2007年第4期|共7页
作者
Rigby WF;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Antibodies; Monoclonal; Antirheumatic Agents; Immunoglobulin G; Tumor Necrosis Factor-alpha; 抗体; 单克隆; 抗风湿药;

机译：Antibodies;Monoclonal;Antirheumatic Agents;Immunoglobulin G;Tumor Necrosis Factor-alpha;抗体;单克隆;抗风湿药;

相似文献

外文文献
中文文献
专利

1. Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior? [J] . Rigby WF Nature clinical practice. Rheumatology . 2007,第4期

机译：药物洞察力：肿瘤坏死因子拮抗剂-被动攻击行为的不同作用机制？
2. Cycling of tumor necrosis factor inhibitors versus switching to different mechanism of action therapy in rheumatoid arthritis patients with inadequate response to tumor necrosis factor inhibitors: a Bayesian network meta-analysis [J] . Alberto Migliore, Giuseppe Pompilio, Davide Integlia, Therapeutic advances in musculoskeletal disease. . 2021,第a期

机译：肿瘤坏死因子抑制剂的循环与类风湿性关节炎患者对不同动作治疗的不同机制，对肿瘤坏死因子抑制剂的反应不足：贝叶斯网络荟萃分析
3. Treatment Persistence and Clinical Outcomes of Tumor Necrosis Factor Inhibitor Cycling or Switching to a New Mechanism of Action Therapy: Real-world Observational Study of Rheumatoid Arthritis Patients in the United States with Prior Tumor Necrosis Factor Inhibitor Therapy [J] . Wenhui Wei, Keith Knapp, Li Wang, Advances in therapy. . 2017,第8期

机译：治疗持续和肿瘤坏死因子抑制剂循环或切换到新的作用治疗机制的临床结果：现实世界观测研究美国类风湿性关节炎患者与先前肿瘤坏死因子抑制作用治疗
4. A HDX/MS analysis of the interaction between human tumor necrosis factor-alpha (TNFα) and anti-TNFαagents [C] . Shiori Nakazawa, Noritaka Hashii, Nana Kawasaki American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：HDX / MS分析人肿瘤坏死因子-α（TNFα）和抗TNFα之间的相互作用
5. Mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction: An in vitro model of idiosyncratic drug-induced liver injury. [D] . Beggs, Kevin Michael. 2013

机译：曲伐沙星-肿瘤坏死因子-α相互作用诱导的肝细胞凋亡机制：特异药物诱导的肝损伤的体外模型。
6. Treatment Persistence and Clinical Outcomes of Tumor Necrosis Factor Inhibitor Cycling or Switching to a New Mechanism of Action Therapy: Real-world Observational Study of Rheumatoid Arthritis Patients in the United States with Prior Tumor Necrosis Factor Inhibitor Therapy [O] . Wenhui Wei, Keith Knapp, Li Wang, -1

机译：肿瘤坏死因子抑制剂循环或转用新的作用机制的治疗持久性和临床结果：美国风湿性关节炎患者接受肿瘤坏死因子抑制剂治疗的现实观察研究
7. A comparative study into the mechanisms of action of anti–tumor necrosis factor α, anti-CD4, and combined anti–tumor necrosis factor α/anti-CD4 treatment in early collagen-induced arthritis [O] . Lilia Marinova-Mutafchieva, Richard O. Williams, Claudia Mauri, 2000

机译：抗肿瘤坏死因子α，抗CD4和抗肿瘤坏死因子α/抗CD4治疗在早期胶原蛋白诱导的关节炎的作用机制的比较研究

Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?

摘要

著录项

相似文献

相关主题

期刊订阅