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Primer: challenges in randomized and observational studies.

机译:入门:随机和观察性研究的挑战。

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摘要

Randomized controlled trials (RCTs) are considered superior to observational studies, and both clinicians and researchers believe that conclusions that stem from observational research are flawed. RCTs, however, have important methodological and interpretational limitations, and particular clinical questions can only be addressed by observational research. This Review compares RCTs and observational studies with regard to particular limitations, and explains how the credibility of results from observational studies can be improved by making use of advanced analytical techniques.
机译:随机对照试验(RCT)被认为优于观察性研究,临床医生和研究人员均认为,源自观察性研究的结论是有缺陷的。然而,RCT具有重要的方法和解释限制,特定的临床问题只能通过观察性研究来解决。这篇评论比较了RCT和观察性研究在特定局限性方面的情况,并解释了如何通过使用先进的分析技术来提高观察性研究结果的可信度。

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