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首页> 外文期刊>Nature clinical practice. Rheumatology >Therapy insight: the use of antirheumatic drugs during nursing.
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Therapy insight: the use of antirheumatic drugs during nursing.

机译：治疗见解：护理期间使用抗风湿药。

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In 90% of cases, women with rheumatoid arthritis suffer a disease flare within 3 months of delivery of their baby. Drug treatment is, therefore, required; however, such therapies have implications for mothers who decide to nurse their infants. Unfortunately, because of a paucity of data, little is known about the transfer of antirheumatic drugs into breast milk, and even less is known about whether small amounts of these agents ingested during nursing could harm the infant. Our review of the literature indicates that paracetamol, prednisone, antimalarial agents, sulfasalazine and most NSAIDs can safely be used by lactating mothers. Expert opinions differ regarding the use of azathioprine, ciclosporin, and methotrexate during lactation because of varying views on the potential for short-term and long-term adverse effects. Evidence regarding the transfer of leflunomide and biologic drugs into breast milk is insufficient; therefore, until more studies are conducted, the use of these drugs in breastfeedingmothers should be restricted. At present, many patients feel they have to choose between postpartum disease control and lactation. Extended studies of the transfer of antirheumatic drugs into breast milk and the resulting consequences are, therefore, urgently needed.
机译：在90％的情况下，类风湿关节炎的妇女在分娩后3个月内会患上疾病。因此，需要药物治疗;然而，这样的疗法对决定护理婴儿的母亲有影响。不幸的是，由于缺乏数据，人们对抗风湿药向母乳中的转移知之甚少，而在哺乳期间摄入的这些抗风湿药是否会损害婴儿也知之甚少。我们对文献的回顾表明，对乙酰氨基酚，泼尼松，抗疟药，柳氮磺胺吡啶和大多数NSAIDs可以由哺乳期母亲安全使用。专家意见在哺乳期间对硫唑嘌呤，环孢素和甲氨蝶呤的使用存在分歧，因为对短期和长期不良影响的可能性存在分歧。关于来氟米特和生物药物转移到母乳中的证据不足;因此，在进行更多研究之前，应限制在母乳喂养母亲中使用这些药物。目前，许多患者感到必须在产后疾病控制和哺乳之间进行选择。因此，迫切需要对抗风湿药向母乳中转移及其产生的后果进行深入研究。

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