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首页> 外文期刊>Nature immunology >Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
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Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.

机译：Themis通过调节T细胞抗原受体介导的信号传导来控制胸腺细胞的选择。

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摘要

Themis (thymocyte-expressed molecule involved in selection), a member of a family of proteins with unknown functions, is highly conserved among vertebrates. Here we found that Themis had high expression in thymocytes between the pre-T cell antigen receptor (pre-TCR) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient thymocytes showed defective positive selection, which resulted in fewer mature thymocytes. Negative selection was also impaired in Themis-deficient mice. A greater percentage of Themis-deficient T cells had CD4(+)CD25(+)Foxp3(+) regulatory and CD62L(lo)CD44(hi) memory phenotypes than did wild-type T cells. In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk.
机译：Themis（参与选择的表达胸腺细胞的分子）是功能未知的蛋白质家族的成员，在脊椎动物中高度保守。在这里，我们发现Themis在T细胞前抗原受体（pre-TCR）和阳性选择检查点之间的胸腺细胞中高表达，在成熟T细胞中低表达。缺乏胸腺的胸腺细胞显示出缺陷的正选择，导致较少的成熟胸腺细胞。 The弥斯缺陷小鼠的阴性选择也受到损害。与野生型T细胞相比，Themis缺陷型T细胞具有更大的CD4（+）CD25（+）Foxp3（+）调节型和CD62L（lo）CD44（hi）记忆表型。为了支持Themis参与TCR信号转导的想法，该蛋白在TCR刺激后迅速磷酸化，是最佳TCR驱动的钙动员和Erk激酶激活所必需的。

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