Blockade of eosinophil migration and airway hyperresponsiveness by cPLA_2-inhibition

Shigeharu Myou; Hiroyuki Sano; Masaki Fujimura; Xiangdong Zhu; Kazuyoshi Kurashima; Toshiyuki Kita; Shinji Nakao; Akitaka Nonomura; Takanobu Shioya; Kwang Pyo Kim; Nilda M. Munoz; Wonhwa Cho; Alan R. Leff

首页> 外文期刊>Nature immunology >Blockade of eosinophil migration and airway hyperresponsiveness by cPLA_2-inhibition

【24h】

Blockade of eosinophil migration and airway hyperresponsiveness by cPLA_2-inhibition

机译：通过cPLA_2抑制作用来阻止嗜酸性粒细胞迁移和气道高反应性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We examined the role of a cytosolic phospholipase A_2 (cPLA_2) in antigen-induced eosinophil infiltration of airways and in airway hyperresponsiveness to methacholine. Inhibition of cPLA_2, or blockade of the platelet-activating factor (PAF) receptor, blocked antigen-induced airway hyperresponsiveness and suppressed eosinophil infiltration. Neither cyclooxygenase nor 5-lipoxygenase inhibition had either effect. We show here that, in antigen-sensitized guinea pigs, cPLA_2 inhibition prevents both eosinophilic infiltration and subsequent airway hyperresponsiveness after antigen challenge. we also show that this effect is mediated by first-step hydrolysis of membrane phospholipid into lysophospholipid rather than by prostanoid or leukotriene metabolites of arachidonate.

机译：我们检查了细胞溶质磷脂酶A_2（cPLA_2）在抗原诱导的气道嗜酸性粒细胞浸润和气道对乙酰甲胆碱高反应性中的作用。抑制cPLA_2或阻断血小板活化因子（PAF）受体可阻断抗原诱导的气道高反应性并抑制嗜酸性粒细胞浸润。环氧合酶和5-脂氧合酶均无抑制作用。我们在这里显示，在抗原致敏的豚鼠中，cPLA_2抑制作用既阻止了嗜酸性粒细胞浸润，又阻止了抗原攻击后随后的气道高反应性。我们还表明，这种作用是由膜磷脂第一步水解为溶血磷脂介导的，而不是由花生四烯酸的前列腺素或白三烯代谢产物介导的。

著录项

来源
《Nature immunology》 |2001年第2期|共5页
作者
Shigeharu Myou; Hiroyuki Sano; Masaki Fujimura; Xiangdong Zhu; Kazuyoshi Kurashima; Toshiyuki Kita; Shinji Nakao; Akitaka Nonomura; Takanobu Shioya; Kwang Pyo Kim; Nilda M. Munoz; Wonhwa Cho; Alan R. Leff;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词

相似文献

外文文献
中文文献
专利

1. Blockade of eosinophil migration and airway hyperresponsiveness by cPLA_2-inhibition [J] . Shigeharu Myou, Hiroyuki Sano, Masaki Fujimura, Nature immunology . 2001,第2期

机译：通过cPLA_2抑制作用来阻止嗜酸性粒细胞迁移和气道高反应性
2. Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs. [J] . Kraneveld AD, van Ark I, Van Der Linde HJ, The Journal of Allergy and Clinical Immunology . 1997,第2期

机译：晚期激活抗原4的抗体可防止白介素5诱导的豚鼠气道高反应性和嗜酸性粒细胞浸润。
3. Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma. [J] . Gibson PG, Saltos N, Borgas T The Journal of Allergy and Clinical Immunology . 2000,第4期

机译：在皮质类固醇治疗的哮喘中，气道肥大细胞和嗜酸性粒细胞与临床严重程度和气道高反应性相关。
4. Sputum Eosinophil Counts and Eosinophil Cationic Protein (ECP) Levels in Cough-Variant Asthma and in Classic Asthma, and Their Relationships to Airway Hypersensitivity or Maximal Airway Response to Methacholine [C] . Young Yoo, Young Yull Koh, Hee Kang Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：痰嗜酸性粒细胞计数和嗜酸铈粒细胞阳离子蛋白（ECP）水平在咳嗽变异哮喘和经典的哮喘，以及它们与气道超敏反应或最大气道对甲磺酸的关系的关系
5. Studies on the growth of smooth muscle from the airways of hyperresponsive rats. [D] . Zacour, Mary Eleanor. 1998

机译：高反应性大鼠气道平滑肌生长的研究。
6. Small-Airway Function Variables in Spirometry Fractional Exhaled Nitric Oxide and Circulating Eosinophils Predicted Airway Hyperresponsiveness in Patients with Mild Asthma [O] . Wuping Bao, Xue Zhang, Junfeng Yin, 2021

机译：小气道函数变量肺活量测定分数呼出一氧化氮循环嗜酸性粒细胞预测气道高反应性患者轻度哮喘患者
7. Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. [O] . Gundel, R H, Letts, L G, Gleich, G J 1991

机译：人嗜酸性粒细胞主要碱性蛋白诱导灵长类动物气道收缩和气道高反应性。

Blockade of eosinophil migration and airway hyperresponsiveness by cPLA_2-inhibition

摘要

著录项

相似文献

相关主题

期刊订阅