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On guard-activating NK cell receptors

机译:关于保护激活的NK细胞受体

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摘要

Although natural killer (NK) cells are known to preferentially kill cells that lack major histocompatibility complex class I antigens, we do not know what signals the attack of these targets. Several membrane receptors have recently been implicated in this process and include molecules with immunoreceptor tyrosine-based activation motifs (ITAM) and motifs that bind phosphoinositide-3 kinase (P13K). Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies.
机译:尽管已知自然杀伤(NK)细胞可优先杀死缺乏主要组织相容性复合I类抗原的细胞,但我们不知道是什么信号提示了这些靶标的攻击。最近,一些膜受体参与了这一过程,包括具有基于免疫受体酪氨酸的活化基序(ITAM)和结合磷酸肌醇3激酶(P13K)的基序的分子。越来越多的证据表明,NK细胞可能使用多种受体和信号传导途径的组合来保护宿主免受感染,并可能抵抗恶性肿瘤。

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