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首页> 外文期刊>Nature immunology >From IL-2 to IL-37: The expanding spectrum of anti-inflammatory cytokines
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From IL-2 to IL-37: The expanding spectrum of anti-inflammatory cytokines

机译:从IL-2到IL-37:抗炎细胞因子的范围不断扩大

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Feedback regulatory circuits provided by regulatory T cells (T reg cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-α (TGF-α) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.
机译:调节性T细胞(T reg细胞)和抑制性细胞因子提供的反馈调节电路是免疫系统的固有组成部分,同时具有效应器功能。在这里,我们讨论了一些调节性细胞因子,这些调节性细胞因子已经进化为对自身成分具有耐受性,并且可以在对宿主造成最小附带损害的情况下消除病原体。白介素2(IL-2),IL-10和转化生长因子-α(TGF-α)的特性已得到很好的表征,而IL-27,IL-35和IL-37代表了抗炎细胞因子谱的新成员。我们还强调了通过基因工程小鼠的体外和体内研究积累的信息如何有助于理解和治疗人类疾病。

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