Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

Hiroaki Hemmi; Tsuneyasu Kaisho; Osamu Takeuchi; Shintaro Sato; Hideki Sanjo; Katsuaki Hoshino; Takao Horiuchi; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira

首页> 外文期刊>Nature immunology >Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

【24h】

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

机译：小型抗病毒化合物通过TLR7 MyD88依赖性信号通路激活免疫细胞

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the synthesis of interferon-α and other cytokines in a variety of cell types. These compounds have potent anti-viral and anti-tumor properties; however, the mechanisms by which they exert their anti-viral activities remain unclear. Here we show that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. In response to the imidazoquinolines, neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells. Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice.

机译：咪唑喹啉化合物咪喹莫特和R-848是低分子量免疫应答调节剂，可诱导多种细胞类型中干扰素-α和其他细胞因子的合成。这些化合物具有有效的抗病毒和抗肿瘤特性。但是，它们发挥抗病毒活性的机制仍不清楚。在这里，我们显示咪唑并喹啉通过Toll样受体7（TLR7）-MyD88依赖性信号通路激活免疫细胞。响应咪唑并喹啉，MyD88和TLR7缺陷型小鼠均未显示出巨噬细胞，脾细胞增殖或树突状细胞成熟引起的任何炎性细胞因子产生。在MyD88和TLR7缺陷型小鼠中，咪唑喹啉诱导的信号转导事件也被消除。

著录项

来源
《Nature immunology》 |2002年第2期|共5页
作者
Hiroaki Hemmi; Tsuneyasu Kaisho; Osamu Takeuchi; Shintaro Sato; Hideki Sanjo; Katsuaki Hoshino; Takao Horiuchi; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词

相似文献

外文文献
中文文献
专利

1. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway [J] . Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Nature immunology . 2002,第2期

机译：小型抗病毒化合物通过TLR7 MyD88依赖性信号通路激活免疫细胞
2. Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway [J] . Osamu Takeuchi, Andreas Kaufmann, Karsten Grote, The journal of immunology . 2000,第2期

机译：尖端：支原体脂肽巨噬细胞激活脂肽2的R-立体异构体通过像Toll样受体2-和MyD88依赖的信号通路激活免疫细胞。
3. Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7–MyD88-Dependent Signaling Pathway [J] . Sophia Davidson, Gerard Kaiko, Zhixuan Loh, The journal of immunology . 2011,第10期

机译：浆细胞样树突状细胞通过TLR7–MyD88依赖性信号通路促进宿主抵抗急性肺病毒感染
4. The Signal Pathways Of Immune Inflammation Mediated By The Tlr3/Nf-Kappab And Activator Protein-1 In Cells Infected With Influenza A Virus Antagonized By Baicalin [C] . Chunjing Zhang, Haitao Yu International Conference on Smart Materials and Nanotechnology in Engineering . 2012

机译：在感染甲虫拮抗的细胞中介导的TLR3 / NF-κB和活化剂蛋白-1介导的免疫炎症的信号途径
5. Long Noncoding RNA Signatures Induced by TLR7 and Type I IFN Signaling in Activated Human Plasmacytoid Dendritic Cells [D] . Joslyn, Rochelle Catherine 2018

机译：TLR7和I型IFN信号转导激活的人浆细胞样树突状细胞中诱导的长非编码RNA特征。
6. The Double-Stranded RNA Bluetongue Virus Induces Type I Interferon in Plasmacytoid Dendritic Cells via a MYD88-Dependent TLR7/8-Independent Signaling Pathway [O] . Suzana Ruscanu, Florentina Pascale, Mickael Bourge, 2012

机译：双链RNA蓝舌病毒通过依赖MYD88的TLR7 / 8独立信号通路诱导浆细胞样树突状细胞中的I型干扰素。
7. The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway. [O] . Ruscanu, Suzana, Pascale, Florentina, Bourge, Mickael, 2012

机译：双链RNA蓝舌病毒通过依赖MYD88的TLR7 / 8独立信号通路在浆细胞样树突状细胞中诱导I型干扰素。

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

摘要

著录项

相似文献

相关主题

期刊订阅