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首页> 外文期刊>Nature immunology >Dynamic visualization of a joint-specific autoimmune response through positron emission tomography
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Dynamic visualization of a joint-specific autoimmune response through positron emission tomography

机译：通过正电子发射断层摄影术动态观察关节特异性自身免疫反应

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摘要

In the K/BxN mouse model of rheumatoid arthritis, the transfer of autoantibodies specific for glucose-6-phosphate isomerase (GPI) into naive mice rapidly induces joint-specific inflammation similar to that seen in human rheumatoid arthritis. The ubiquitous expression of GPI and the systemic circulation of anti-GPI immunoglobulin G (IgG) seem incongruous with the tissue specificity of this disease. By using PET (positron emission tomography), we show here that purified anti-GPI IgG localizes specifically to distal joints in the front and rear limbs within minutes of intravenous injection, reaches saturation by 20 min and remains localized for at least 24 h. In contrast, control IgG does not localize to joints or cause inflammation. The rapid kinetics of anti-GPI IgG joint localization supports a model in which autoantibodies bind directly to pre-existing extracellular GPI in normal healthy mouse joints.
机译：在类风湿关节炎的K / BxN小鼠模型中，特异于葡萄糖6磷酸异构酶（GPI）的自身抗体转移到幼稚小鼠中后，会迅速诱发类似于人类风湿关节炎的关节特异性炎症。 GPI的普遍表达和抗GPI免疫球蛋白G（IgG）的全身循环似乎与该疾病的组织特异性不一致。通过使用PET（正电子发射断层扫描），我们在这里显示纯化的抗GPI IgG特异性地在静脉注射的几分钟内定位于前后肢的远端关节，到20分钟达到饱和并保持定位至少24 h。相反，对照IgG不会定位于关节或引起炎症。抗GPI IgG关节定位的快速动力学支持了一种模型，其中自身抗体直接与正常健康小鼠关节中预先存在的细胞外GPI结合。

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