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Is pregabalin a safe and effective treatment for patients with fibromyalgia?

机译：普瑞巴林对纤维肌痛患者是否安全有效？

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The concept of fibromyalgia being one of several 'central sensitivity syndromes' has led to the use of centrally acting drugs in the treatment of this disorder. One such drug, pregabalin, has recently been approved by the US FDA for the treatment of fibromyalgia. In a study by Mease and colleagues, significant relief from symptomatic pain was achieved in patients treated with pregabalin 300 mg/day, 450 mg/day and 600 mg/day compared with placebo. In addition, Patient Global Impression of Change and sleep scale scores were significantly improved in all treatment groups at the i 3:week end point. Dizziness and somnolence were the two most common dose-related adverse events, but led to few withdrawals from the study. The results support the use of pregabalin as a mechanism-based treatment for pain and sleep disturbances in patients with fibromyalgia. Further studies with a longer observation period and randomized trials comparing different medications are needed.
机译：纤维肌痛的概念是几种“中央敏感性综合症”之一，已导致在这种疾病的治疗中使用中枢作用药物。一种这样的药物普瑞巴林（pregabalin）最近已被美国FDA批准用于治疗纤维肌痛。在Mease及其同事的一项研究中，与安慰剂相比，接受普瑞巴林300 mg /天，450 mg /天和600 mg /天治疗的患者可明显缓解症状性疼痛。此外，在第3周结束时，所有治疗组的患者总体变化印象和睡眠量表得分均得到显着改善。头晕和嗜睡是两个最常见的剂量相关不良事件，但导致该研究退出的人数很少。结果支持普瑞巴林作为一种基于机制的治疗肌纤维痛患者的疼痛和睡眠障碍的方法。需要进行更长的观察期的进一步研究以及比较不同药物的随机试验。

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