• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature clinical practice. Rheumatology >Primer: inflammasomes and interleukin 1beta in inflammatory disorders.
【24h】

Primer: inflammasomes and interleukin 1beta in inflammatory disorders.

机译：引物：炎性疾病中的炎症小体和白介素1β。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Inflammasomes are large, multimeric protein complexes that link the sensing of microbial products and metabolic stress to the proteolytic processing of prointerleukin (pro-IL)-1beta to its active form. NALP1 and NALP2 are founding members of the Nod-like receptor family. Other Nod-like receptors, including NALP3 and NOD2, which are associated with inflammatory disorders, have also been described. The NALP1 and NALP3 inflammasomes are located in the cytoplasm and can, therefore, detect intracellular infection through recognition of microbial pathogen-associated molecular patterns. The inflammasome pathways cooperate with Toll-like receptor pathways to mediate a rapid and appropriate response to pathogens and genotoxic stress. Mutations in both pyrin and NALP3 components of inflammasomes are associated with innate-immune-mediated diseases (familial Mediterranean fever and the 'cryopyrinopathies'), and aberrant IL-1beta processing has been reported in several autoinflammatory conditions, including Muckle-Wells syndrome, chronic infantile neurologic, cutaneous and articular syndromeeonatal onset multisystem inflammatory disease, and gout. The effectiveness of IL-1beta blockade in treating many of these conditions has transformed the understanding and management of these disorders and also highlighted the role of aberrant IL-1beta signaling in other conditions, such as adult-onset Still's disease and systemic juvenile idiopathic arthritis.
机译：炎症小体是大型的，多聚体的蛋白质复合物，将微生物产物的感应和代谢应激与前白介素（pro-IL）-1beta的蛋白水解过程转变成其活性形式有关。 NALP1和NALP2是Nod样受体家族的创始成员。还已经描述了与炎症性疾病有关的其他Nod样受体，包括NALP3和NOD2。 NALP1和NALP3炎性体位于细胞质中，因此可以通过识别微生物病原体相关的分子模式来检测细胞内感染。炎性体途径与Toll样受体途径协同作用，以介导对病原体和遗传毒性应激的快速而适当的反应。炎性小体的吡啶和NALP3组分的突变均与先天免疫介导的疾病（家族性地中海热和“隐睾病”）有关，并且在多种自身炎症性疾病中报告了异常的IL-1beta加工，包括Muckle-Wells综合征，慢性婴儿神经系统，皮肤和关节综合征/新生儿发作多系统炎性疾病和痛风。 IL-1beta阻滞在治疗许多这些疾病中的有效性改变了对这些疾病的理解和管理，并突显了异常的IL-1beta信号转导在其他疾病中的作用，例如成年性斯蒂尔氏病和系统性幼年特发性关节炎。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号