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首页> 外文期刊>Nature clinical practice. Rheumatology >Genetics of osteoarthritis: early developmental clues to an old disease
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Genetics of osteoarthritis: early developmental clues to an old disease

机译：骨关节炎的遗传学：一种旧疾病的早期发育线索

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About 15 years ago, it was considered questionable whether genetic research into a so-called wear-and-tear disease, such as osteoarthritis (OA), would provide any useful insight. Since then, a number of middle-aged patient populations have been investigated in the quest for OA susceptibility genes. The best genetic studies have revealed that OA is a degenerative disease seen in people of advanced age, which involves cartilage maintenance functions, determinants of bone composition and an intriguing developmental component.OA is the most common chronic joint disease in the elderly. Radiographic signs of OA correspond with the aging process of joints and, in approximately 50% of affected individuals, are associated with clinical manifestations, such as chronic pain, joint stiffness and long-term disability. Current treatment is mainly limited to drug-based pain relief and total joint replacement. Trauma, obesity, age and genetic factors are the culprits of OA pathogenesis. Genetic predisposition is relevant for different definitions of OA, based on the affected joint site and on progression of the disease.
机译：大约15年前，人们对所谓的“磨损性疾病”（如骨关节炎（OA））的基因研究是否能提供任何有用的见解存在疑问。从那时起，已经对许多中年患者人群进行了研究，以寻找OA敏感性基因。最好的遗传学研究表明，OA是一种在老年人中出现的退化性疾病，它涉及软骨维持功能，骨骼组成的决定因素和有趣的发育成分。OA是老年人中最常见的慢性关节疾病。 OA的放射线体征与关节的衰老过程相对应，在大约50％的受影响个体中，其与临床表现有关，例如慢性疼痛，关节僵硬和长期残疾。当前的治疗方法主要限于药物缓解疼痛和全关节置换。创伤，肥胖，年龄和遗传因素是OA发病的元凶。基于受影响的关节部位和疾病进展，遗传易感性与OA的不同定义有关。

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