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首页> 外文期刊>Nature clinical practice. Oncology >Human papillomavirus in cervical and head-and-neck cancer.
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Human papillomavirus in cervical and head-and-neck cancer.

机译:人乳头瘤病毒在宫颈癌和头颈癌中的作用。

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摘要

Cervical cancer is a major cause of cancer mortality in women worldwide and is initiated by infection with high-risk human papillomaviruses (HPVs). High-risk HPVs, especially HPV-16, are associated with other anogenital cancers and a subgroup of head-and-neck cancers. Indeed, HPV infection could account for the development of head-and-neck cancer in certain individuals that lack the classical risk factors for this disease (tobacco and alcohol abuse). This Review summarizes the main events of the HPV life cycle, the functions of the viral proteins, and the implications of HPV infection on their hosts, with an emphasis on carcinogenic mechanisms and disease outcomes in head-and-neck cancer. The demonstration that HPVs have a role in human carcinogenesis has allowed the development of preventive and therapeutic strategies aimed at reducing the incidence and mortality of HPV-associated cancers.
机译:宫颈癌是全世界女性癌症死亡的主要原因,并且是由高危人类乳头瘤病毒(HPV)感染引起的。高风险的HPV,尤其是HPV-16,与其他肛门生殖器癌症和头颈癌亚组有关。确实,HPV感染可导致某些缺乏典型疾病危险因素(烟草和酒精滥用)的个体发展为头颈癌。这篇综述总结了HPV生命周期的主要事件,病毒蛋白的功能以及HPV感染对其宿主的影响,并着重介绍了头颈癌的致癌机制和疾病结局。 HPV在人类致癌作用中的作用已得到证实,从而为预防和治疗策略的发展做出了努力,旨在降低与HPV相关的癌症的发病率和死亡率。

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