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首页> 外文期刊>Nature clinical practice. Oncology >Transplantation of allogeneic hematopoietic stem cells: an emerging treatment modality for solid tumors.
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Transplantation of allogeneic hematopoietic stem cells: an emerging treatment modality for solid tumors.

机译：同种异体造血干细胞的移植：一种针对实体瘤的新兴治疗方式。

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Allogeneic transplantation of hematopoietic cells from an HLA-compatible donor has been used to treat hematologic malignancies. Allogeneic transplantation not only replaces the marrow affected by the disease, but exerts an immune graft-versus-tumor (GVT) effect mediated by donor lymphocytes. The development of nonmyeloablative conditioning regimens before allogeneic transplantation has allowed this therapy to be used in elderly and disabled patients. An allogeneic GVT effect is observed in a proportion of patients with renal, breast, colorectal, ovarian, and pancreatic cancer treated with allogeneic transplantation. In general, the tumor response is associated with the development of acute and chronic graft-versus-host disease. Further improvements will depend on the identification of the antigen targets of GVT, and on reduction of the toxicity of the procedure. Targeted therapies may complement the immune effect of allogeneic transplantation. We present updated results from the literature and data recently placed on file at the European Bone Marrow Transplantation Solid Tumors Working Party.
机译：来自HLA相容供体的造血细胞的同种异体移植已用于治疗血液系统恶性肿瘤。同种异体移植不仅替代了受疾病影响的骨髓，而且还发挥了供体淋巴细胞介导的免疫移植物抗肿瘤（GVT）作用。同种异体移植之前非清髓性调理方案的发展使该疗法可用于老年和残疾患者。在同种异体移植治疗的肾癌，乳腺癌，结直肠癌，卵巢癌和胰腺癌患者中，观察到同种异体GVT的作用。通常，肿瘤反应与急性和慢性移植物抗宿主病的发展有关。进一步的改进将取决于对GVT抗原靶标的鉴定，并取决于该方法毒性的降低。靶向疗法可以补充同种异体移植的免疫效果。我们介绍了最近在欧洲骨髓移植实体瘤工作组存档的文献和数据的最新结果。

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