Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.

Barbour SJ; Beaulieu MC; Zalunardo NY; Magil AB

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Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.

机译：增生性肾小球肾炎，继发于慢性淋巴细胞性白血病的单克隆IgG沉积物。报告两例。

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Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a recently described entity that is only rarely associated with a hematological or lymphoproliferative malignancy. We describe the cases of two men with preexisting chronic lymphocytic leukemia (CLL) who developed endocapillary proliferative glomerulonephritis with nonorganized monoclonal IgG(1) deposits. One biopsy also showed CLL infiltration of the cortex. Both patients were treated with rituximab in addition to cyclophosphamide in one case and fludarabine in the other with significant improvement of their renal disease and CLL. This report provides additional evidence to support the use of rituximab in the therapy of CLL-associated PGNMID.

机译：具有单克隆IgG沉积物（PGNMID）的增生性肾小球肾炎是最近描述的一种实体，很少与血液学或淋巴增生性恶性肿瘤相关。我们描述了两名患有慢性淋巴细胞性白血病（CLL）的男性患者的案例，这些患者发展出无组织单克隆IgG（1）沉积的毛细血管内增生性肾小球肾炎。一项活检还显示CLL浸润了皮质。两名患者除环磷酰胺和氟达拉滨外，还分别用利妥昔单抗和氟达拉滨治疗，均显着改善了肾脏疾病和CLL。该报告提供了其他证据来支持利妥昔单抗在CLL相关性PGNMID治疗中的应用。

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《Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association》 |2011年第8期|共3页
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Barbour SJ; Beaulieu MC; Zalunardo NY; Magil AB;
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1. Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases. [J] . Barbour SJ, Beaulieu MC, Zalunardo NY, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2011,第8期

机译：增生性肾小球肾炎，继发于慢性淋巴细胞性白血病的单克隆IgG沉积物。报告两例。
2. Proliferative glomerulonephritis with monoclonal IgM-κ deposits in chronic lymphocytic leukemia/small lymphocytic leukemia: case report and review of the literature [J] . Yuji Oe, Kensuke Joh, Mitsuhiro Sato, CEN Case Reports . 2013,第2期

机译：慢性淋巴细胞白血病/小淋巴细胞白血病中具有单克隆IgM-κ沉积物的增生性肾小球肾炎：病例报告和文献复习
3. Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IGG2λ subtype in a transplanted kidney: A case report [J] . SumidaK., UbaraY., MaruiY., American Journal of Kidney Diseases: The official journal of the National Kidney Foundation . 2013,第3期

机译：移植肾中复发性增生性肾小球肾炎伴有IGG2λ亚型的单克隆IgG沉积物：一例报告
4. Effects of Secondary Stucture on Deamidation of the Fc Portion of Recombinant Monoclonal Antibody IgG [C] . Sandipan Sinha, Lei Zhang, Todd Williams, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：重组单克隆抗体IgG的Fc部分脱酰基二次结构的影响
5. Effect of low density lipoproteins on the progression of chronic lymphocytic leukemia. [D] . McCaw, Lindsay Victoria. 2016

机译：低密度脂蛋白对慢性淋巴细胞性白血病进展的影响。
6. Proliferative glomerulonephritis with monoclonal IgM-κ deposits in chronic lymphocytic leukemia/small lymphocytic leukemia: case report and review of the literature [O] . Yuji Oe, Kensuke Joh, Mitsuhiro Sato, 2013

机译：慢性淋巴细胞白血病/小淋巴细胞白血病中具有单克隆IgM-κ沉积物的增生性肾小球肾炎：病例报告和文献复习
7. Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases [O] . S. J. Barbour, M. C. Beaulieu, N. Y. Zalunardo, 2011

机译：具有二次慢性淋巴细胞白血病的单克隆IgG沉积物的增殖性肾小球肾炎。报告两种情况

Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases.

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