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New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.

机译:来自蘑菇灵芝的新灵芝酸,具有生物活性的三萜类代谢物。

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摘要

Two new lanostanoids, 7-oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.
机译:从灵芝子实体的亲脂性提取物中分离出两个新的类胡萝卜素类化合物,即7-氧代-灵芝酸Z(1)和15-羟基-灵芝S(2)。两种化合物的结构都是通过解释其光谱数据确定的。化合物1和2均显示出对HMG-CoA还原酶和酰基CoA酰基转移酶的抑制活性。

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