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首页> 外文期刊>Natural product research >Antitumoural activity of viniferin- enriched extracts from Vitis vinifera L. cell cultures
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Antitumoural activity of viniferin- enriched extracts from Vitis vinifera L. cell cultures

机译：葡萄果实细胞培养物中富含酿酒素的提取物的抗肿瘤活性

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The aim of this work was to evaluate the effect of stilbenes from different cultivars of Vitis vinifera on tumour proliferation. Extracts were obtained from elicited V. vinifera cell cultures and characterised by HPLC/DAD/MS. Cell growth was evaluated in four human cancer cell lines and in normal human fibroblasts. The cells were exposed to the extracts or to trans-resveratrol, used as reference molecule, for 48 h, at 1-10 mu M concentrations of total stilbenoids. All the extracts exhibited antiproliferative activity, mediated by modulation of the cell cycle and induction of cytotoxicity in cancer but not in normal cell lines, and positively correlated with the content in dimeric stilbenoids. The Alphonse Lavallee extract was the most active, and the obtained stilbenoid fraction resulted 8-10 times more active than trans-resveratrol. Extracts from V. vinifera cell cultures could represent new sources of active stilbenoid compounds to be further assayed in in vivo studies for their antitumoural properties.
机译：这项工作的目的是评估不同品种葡萄中的对苯二酚对肿瘤增殖的影响。提取物得自诱导的葡萄细胞培养物，并通过HPLC / DAD / MS表征。在四种人类癌细胞系和正常人类成纤维细胞中评估了细胞生长。将细胞暴露于提取物或用作参考分子的反白藜芦醇48小时，浓度为1-10μM的总类胡萝卜素。所有提取物均表现出抗增殖活性，其在癌症中由细胞周期的调节和细胞毒性的诱导介导，而在正常细胞系中则没有，并且与二聚体类芪的含量呈正相关。 Alphonse Lavallee提取物的活性最高，所获得的Stilbenoid馏分的活性是反式白藜芦醇的8-10倍。 V. vinifera细胞培养物中的提取物可能代表了活性二苯乙烯类化合物的新来源，将在体内研究中进一步分析其抗肿瘤特性。

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