...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Natural product research >Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice
【24h】

Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice

机译：从胡椒胡椒中提取的黄酮类化合物PMT1和PMT2对小鼠的镇痛和抗炎作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, we identified the antinociceptive and anti-inflammatory effects of two flavonoids (PMT1 and PMT2) from Piper montealegreanum. The antinociceptive effect was evaluated using the classical tests: acetic acid-induced writhing, formalin and hot plate test. PMT1 and PMT2 (0.1, 1, 30 and 100 μmol/kg, i.p.) reduced the writhings, with an ID50 of 0.58 and 0.44 μmol/kg, respectively. Moreover, these flavonoids (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin test, but only PMT2 was active in the inflammatory phase. However, PMT1 and PMT2 (100 μmol/kg, i.p.) did not increase the latency time of the animals in the hot plate. In order to evaluate the anti-inflammatory effect of these flavonoids, capsaicin-induced ear oedema was carried out. Both flavonoids (100 μmol/kg, i.p.) were active in this model. These results suggest that PMT1 and PMT2 have antinociceptive and anti-inflammatory activities.
机译：在这项研究中，我们确定了来自胡椒的两个黄酮类化合物（PMT1和PMT2）的抗伤害性和抗炎作用。使用经典测试评估抗伤害感受作用：乙酸诱导的扭体，福尔马林和热板测试。 PMT1和PMT2（0.1、1、30和100μmol/ kg，腹膜内）降低了扭动，ID50分别为0.58和0.44μmol/ kg。此外，这些黄酮类化合物（100μmol/ kg，腹膜内）在福尔马林试验的神经发生期抑制爪舔时间，但只有PMT2在炎症期具有活性。但是，PMT1和PMT2（100μmol/ kg，i.p.）不会增加动物在热板上的潜伏时间。为了评估这些类黄酮的抗炎作用，进行了辣椒素诱导的耳水肿。这两种黄酮（100μmol/ kg，i.p.）在该模型中均具有活性。这些结果表明，PMT1和PMT2具有抗伤害性和抗炎活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号