Kidney cancer: Temsirolimus fails to expand its role in patients with mRCC

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Kidney cancer: Temsirolimus fails to expand its role in patients with mRCC

机译：肾癌：替罗罗莫司未能扩大其在mRCC患者中的作用

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Mammalian target of rapamycin (mTOR) inhibitor temsirolimus failed to demonstrate superior outcomes to standard therapies for metastatic renal cell carcinoma (mRCC) in two recently published phase III trials.The first trial was set up to investigate whether the combination of temsirolimus and bevacizumab could provide any benefit over interferon-a plus bevacizumab in treatment-naive patients. Both temsirolimus and bevacizumab have modest clinical activity in mRCC but target different pathways (bevacizumab is a monoclonal antibody against vascular endothelial growth factor [VEGF]), making combination therapy a reasonable strategy to explore.

机译：雷帕霉素（mTOR）抑制剂西罗莫司的哺乳动物靶点在两项最近发表的三期转移性肾细胞癌（mRCC）的治疗中均未显示出优于标准疗法的结果。第一个试验旨在研究替西罗莫司和贝伐单抗的组合能否提供治疗效果初治患者比干扰素-a加贝伐单抗的任何获益。替西罗莫司和贝伐单抗在mRCC中均具有适度的临床活性，但靶向不同的途径（贝伐单抗是针对血管内皮生长因子[VEGF]的单克隆抗体），因此联合治疗成为一种合理的研究策略。

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《Nature reviews. Urology》 |2014年第1期|共1页
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Kidney cancer: Temsirolimus fails to expand its role in patients with mRCC [J] . Nature reviews. Urology . 2014,第1期

机译：肾癌：替罗罗莫司未能扩大其在mRCC患者中的作用
2. 1108 POSTER Health-related quality of life (HRQOL) and kidney cancer-related symptoms in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib versus interferon (IFN)-alfa: results for European and US subsample analyses in a randomized, multinational phase III trial [J] . D.Cella, J.Z.Li, A.G.Bushmakin, European Journal of Cancer Supplements . 2007,第4期

机译：1108海报舒尼替尼与干扰素（α）治疗的转移性肾细胞癌（mRCC）患者的健康相关生活质量（HRQOL）和肾癌相关症状：欧洲和美国随机，多国三期试验
3. Temsirolimus in daily use: Results of a prospective multicentre noninterventional study of patients with metastatic kidney cancer [J] . SchraderA.J., SesekeS., KeilC., European urology . 2014,第2期

机译：日常使用的Temsirolimus：转移性肾癌患者的前瞻性多中心非干预性研究结果
4. Neural network design for the recurrence prediction of post-operative non-metastatic kidney cancer patients [C] . Baran Tander, Atilla zmen, Ender zden International Conference on Electrical and Electronics Engineering . 2015

机译：神经网络设计用于术后非转移性肾癌患者复发预测
5. Evaluating Changes in Patient Anxiety Regarding Classic Cancer Genetic Testing Versus Expanded Multiplex Cancer Genetic Testing [D] . Alfonso, Andrew Todd 2015

机译：评估患者对经典癌症基因测试与扩展的多重癌症基因测试的焦虑变化
6. Addition of Bevacizumab to Temsirolimus in Kidney Cancer Patients [O] . H. Boyle, S. Négrier 2011

机译：肾癌患者将贝伐单抗添加到替莫罗莫司中
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Kidney cancer: Temsirolimus fails to expand its role in patients with mRCC

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