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首页> 外文期刊>Nature reviews. Urology >The effect of obesity on sperm disorders and male infertility
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The effect of obesity on sperm disorders and male infertility

机译：肥胖对精子疾病和男性不育的影响

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The results of several studies point to an increased likelihood of abnormal semen parameters among overweight men, and an elevated risk for subfertility among couples in which the male partner is obese. Obesity is, therefore, associated with a higher incidence of male factor infertility. Several mechanisms might account for the effect of obesity on male infertility, both directly and indirectly, by inducing sleep apnea, alterations in hormonal profiles (reduced inhibin B and androgen levels accompanied by elevated estrogen levels) and increased scrotal temperatures, ultimately manifesting as impaired semen parameters (decreased total sperm count, concentration and motility; increased DNA fragmentation index). Neither the reversibility of obesity-associated male infertility with weight loss nor effective therapeutic interventions have been studied in-depth. The increasing prevalence of obesity calls for greater clinical awareness of its effects on fertility, better understanding of underlying mechanisms, and exploration into avenues of treatment.
机译：几项研究的结果表明，超重男性中精液参数异常的可能性增加，而男性伴侣肥胖的夫妇中的不育风险也增加。因此，肥胖与男性不育症的发生率更高有关。几种机制可能通过诱发睡眠呼吸暂停，激素水平变化（抑制素B和雄激素水平降低以及雌激素水平升高）和阴囊温度升高直接或间接地导致了肥胖对男性不育的影响，最终表现为精液受损参数（减少的精子总数，浓度和活力;增加的DNA碎片指数）。肥胖相关的男性不育与体重减轻的可逆性或有效的治疗干预措施均未得到深入研究。肥胖症的日益流行，要求人们对其肥胖症的影响产生更多的临床认识，更好地了解其潜在机制，并探索治疗途径。

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