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首页> 外文期刊>Nature reviews. Urology >Hexaminolevulinate blue-light cystoscopy in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on appropriate use in the USA.
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Hexaminolevulinate blue-light cystoscopy in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on appropriate use in the USA.

机译：非肌肉浸润性膀胱癌中的己氨基乙酰丙酸酯蓝光膀胱镜检查：在美国适当使用的临床证据和共识声明的综述。

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摘要

Hexaminolevulinate (HAL) is a tumour photosensitizer that is used in combination with blue-light cystoscopy (BLC) as an adjunct to white-light cystoscopy (WLC) in the diagnosis and management of non-muscle-invasive bladder cancer (NMIBC). Since being licensed in Europe in 2005, HAL has been used in >200,000 procedures, with consistent evidence that it improves detection compared with WLC alone. Current data support an additional role in the reduction of recurrence of NMIBC. Since the approval of HAL by the FDA in 2010, experience of HAL-BLC in the USA continues to expand. To define areas of need and to identify the benefits of HAL-BLC in clinical practice, a focus group of expert urologists specializing in the management of patients with bladder cancer convened to review the clinical evidence, share their experiences and reach a consensus regarding the optimal use of HAL-BLC in the USA. The focus group concluded that HAL-BLC should be considered for initial assessment of NMIBC, surveillance for recurrent tumours, diagnosis in patients with positive urine cytology but negative WLC findings, and for tumour staging.
机译：己氨基乙酰丙酸酯（HAL）是一种肿瘤光敏剂，可与蓝光膀胱镜检查（BLC）结合使用，作为白光膀胱镜检查（WLC）的辅助手段，用于诊断和管理非肌肉浸润性膀胱癌（NMIBC）。自2005年在欧洲获得许可以来，HAL已用于超过200,000例程序中，有充分的证据表明，与仅使用WLC相比，它可以提高检测效率。当前数据支持减少NMIBC复发的其他​​作用。自2010年FDA批准HAL以来，HAL-BLC在美国的经验不断扩展。为了确定需要的领域并确定HAL-BLC在临床实践中的益处，专门研究膀胱癌患者的专家泌尿科专家小组召开会议，审查临床证据，分享他们的经验并就最佳疗法达成共识。在美国使用HAL-BLC。焦点小组得出结论，应考虑使用HAL-BLC进行NMIBC的初始评估，监测复发肿瘤，尿液细胞学检查阳性但WLC阴性的患者的诊断以及肿瘤分期。

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