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首页> 外文期刊>Neoplasma: Journal of Experimental and Clinical Oncology >Relationship of resistin levels with endometrial cancer risk.
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Relationship of resistin levels with endometrial cancer risk.

机译：抵抗素水平与子宫内膜癌风险的关系。

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摘要

Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects. Keywords: Endometrial cancer, resistin, SNP -420C>G.
机译：子宫内膜癌（CAE）是工业化国家中最常见的妇科恶性肿瘤。近来，抵抗素水平的提高（由脂肪组织和巨噬细胞产生的脂肪细胞因子）被认为是胃癌，结肠癌和乳腺癌的危险因素。迄今为止，尚未进行将抵抗素水平与子宫内膜癌相关的研究。该病例对照研究的目的是确定子宫内膜癌患者血清循环抵抗素水平与抵抗素基因-420C> G（rs3219175）变异之间的关系。这项研究纳入了37位白人女性患者和39位健康对照。年龄与BMI匹配患者组（平均24.2 ng / ml）和对照组（平均10.1 ng / ml）之间的抵抗素水平差异在抵抗素基因内具有统计学意义（p G（rs3219175）），并且抵抗素水平与研究的多态性之间无显着关联此外，在研究组中未观察到更高的抵抗素水平与糖尿病2，体重指数，吸烟或年龄之间的显着相关性，据我们所知，这是第一项研究血清抵抗素水平与子宫内膜癌之间关系的研究。我们的结果表明，子宫内膜癌患者的抵抗素循环水平明显高于正常对照组关键词：子宫内膜癌抵抗素SNP -420C> G。

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