Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

Rasmussen HB.; Branner S.; Wiberg FC.; Wagtmann N.

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Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

机译：人二肽基肽酶IV / CD26与底物类似物的晶体结构

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Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines and neuropeptides. We have determined the 2.5 Angstrom structure of the extracellular region of DPP-IV in complex with the inhibitor valine-pyrrolidide. The catalytic site is located in a large cavity formed between the alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain. Both domains participate in inhibitor binding. The structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site. [References: 35]

机译：二肽基肽酶IV（DPP-IV / CD26）是多功能的II型跨膜丝氨酸肽酶。该酶通过裂解肽激素，趋化因子和神经肽，有助于调节各种生理过程，包括血糖稳态。我们已经确定了与抑制剂缬氨酸-吡咯烷化物复合的DPP-IV胞外区的2.5埃结构。催化位点位于α/β-水解酶结构域和八叶β-螺旋桨结构域之间形成的大空腔中。两个结构域均参与抑制剂结合。该结构指示了如何实现底物特异性，并揭示了活性位点的新的和意外的开放。 [参考：35]

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《Nature structural biology》 |2003年第1期|共7页
作者
Rasmussen HB.; Branner S.; Wiberg FC.; Wagtmann N.;
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正文语种 eng
中图分类生物科学;
关键词
Improved glucose-tolerance; Glucagon-like peptide-1; Beta-propeller domain; Adenosine-deaminase; In-vivo; Iv; Cd26; Association; Inhibition; Secretion;

机译：改善的葡萄糖耐量;胰高血糖素样肽-1;β-螺旋结构域;腺苷脱氨酶;体内;IV;Cd26;缔合;抑制;分泌;

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1. Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog [J] . Rasmussen HB., Branner S., Wiberg FC., Nature structural biology . 2003,第1期

机译：人二肽基肽酶IV / CD26与底物类似物的晶体结构
2. Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation in vitro independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding. [J] . Yu DM, Slaitini L, Gysbers V, Scandinavian journal of immunology. . 2011,第2期

机译：可溶性CD26 /二肽基肽酶IV增强了人淋巴细胞的体外增殖能力，而与二肽基肽酶活性和腺苷脱氨酶结合无关。
3. Crystal Structures of Human Dipeptidyl Peptidase IV in its Apo and Diprotin B-complexed Forms [J] . Hajime Hiramatsu1 Kiyoshi Kyono1 Atsushi Yamamoto1 Kazuhiko Saeki1 Hideaki Shima2 Shigeru Sugiyama34 Koji Inaka3 and Ryo Shimizu1 Acta Biochimica et Biophysica Sinica . 2007,第5期

机译：Apo和Diprotin B复合形式的人二肽基肽酶IV的晶体结构
4. Inhibition of human immunodeficiency virus type 1 infection in a T-cell line(CEM) by new dipeptidyl-peptidase IV (CD26) inhibitors [C] . J.D.Jiang, S.Willk, J.Li, Second workshop related to HIV/AIDS in China . 1999

机译：新的二肽基肽酶IV（CD26）抑制剂抑制T细胞系（CEM）中的人类1型免疫缺陷病毒感染
5. Regulation of HT-29 colorectal carcinoma cell proliferation and cell-surface expression of dipeptidyl peptidase IV (DPPIV)/CD26 and CXCR4 by FGF-2 and other growth factors. [D] . Bseso, Bassma Nader. 2008

机译：FGF-2和其他生长因子对HT-29大肠癌细胞增殖和二肽基肽酶IV（DPPIV）/ CD26和CXCR4的细胞表面表达的调节。
6. Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation [O] . Kathleen Aertgeerts, Sheng Ye, Mike G. Tennant, 2004

机译：人二肽基肽酶IV与十肽复合的晶体结构揭示了底物特异性和四面体中间体形成的细节
7. Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation [O] . Aertgeerts, Kathleen, Ye, Sheng, Tennant, Mike G., 2004

机译：人二肽基肽酶IV与十肽复合的晶体结构揭示了底物特异性和四面体中间体形成的细节

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog

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