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首页> 外文期刊>Neurourology and urodynamics. >Current perception thresholds in the lower urinary tract: Sine- and square-wave currents studied in young healthy volunteers.
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Current perception thresholds in the lower urinary tract: Sine- and square-wave currents studied in young healthy volunteers.

机译：下尿路的电流感知阈值：在年轻健康志愿者中研究的正弦波和方波电流。

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AIMS: To establish normative current perception threshold (CPT) values with neuroselective sine-wave current in the lower urinary tract and to compare these values with square-wave current CPTs. MATERIALS AND METHODS: 10 female and 8 male healthy volunteers were used for this study. A filling cystometry was performed and CPTs were determined with square-wave current at a frequency of 2.5 Hz and with neuroselective sine-wave current at 5 (C-fiber), 250 (Adelta-fiber), and 2000 Hz (Abeta-fiber) in the bladder, the posterior, and the distal urethra. RESULTS: Bladder CPTs were significantly higher compared with CPTs in the posterior urethra (P < 0.028) and in the distal urethra (P < 0.002) with all three sine-wave frequencies. No significant difference was found with any sine-wave frequency between the posterior and distal urethra (P > 0.30). Using square-wave pulses at 2.5 Hz, CPTs decreased towards the distal urethra, with a significant difference between the three stimulation sites (P < 0.0001). At all sites tested, the CPT's determined with sine-wave current at 2000 Hz were significantly higher than those at 250 Hz (P < 0.002) and 5 Hz (P < 0.001). No significant difference was found between 5 Hz and 250 Hz at any site in the LUT (P > 0.50). At all sites, CPTs determined with square-wave pulses at 2.5 Hz were significantly higher than those determined with sine-wave current at all frequencies (P < 0.001). CPTs determined with all sine-wave currents were not correlated with CPTs using square-wave pulses. There was no correlation between the volumes at which sensation of filling occurred and the CPTs. CONCLUSIONS: We described normative values in young healthy volunteers at three sites in the LUT using sine-wave current. Although this type of current is said to be neuroselctive, this needs to be confirmed. Stimulation with sine-wave current is different and might be more physiologic compared to square-wave stimulation. Our data show that sine-wave current stimulation at 5 Hz, 250 Hz, and 2000 Hz can probablynot be used as a semi-objective measurement of the sensation of bladder filling because no correlation was found between CPTs and the cystometeric sensation of filling.
机译：目的：建立下尿路神经选择性正弦波电流的规范电流感知阈值（CPT）值，并将这些值与方波电流CPT进行比较。材料与方法：本研究使用了10名女性和8名男性健康志愿者。进行填充性膀胱测压，并以2.5 Hz的方波电流和5（C纤维），250（Adelta纤维）和2000 Hz（Abeta纤维）的神经选择性正弦波电流确定CPT。在膀胱，后部和远端尿道中。结果：在所有三个正弦波频率下，膀胱CPT均比后尿道（P <0.028）和远端尿道（P <0.002）的CPT高。后尿道与远端尿道之间的任何正弦波频率均无显着差异（P> 0.30）。使用2.5 Hz的方波脉冲，CPT向着尿道远端减少，三个刺激部位之间存在显着差异（P <0.0001）。在所有测试的站点上，使用2000 Hz正弦波电流确定的CPT明显高于250 Hz（P <0.002）和5 Hz（P <0.001）的CPT。在LUT中的任何位置，在5 Hz和250 Hz之间均未发现显着差异（P> 0.50）。在所有站点，在所有频率下，由方波脉冲在2.5 Hz下确定的CPT均显着高于由正弦波电流确定的CPT（P <0.001）。使用正弦波电流确定的CPT与使用方波脉冲的CPT不相关。发生充盈感的体积与CPT之间没有相关性。结论：我们使用正弦波电流描述了LUT中三个位置的年轻健康志愿者的标准值。尽管据说这种电流是神经选择的，但这需要确认。与方波刺激相比，用正弦波电流刺激可能有所不同，并且可能更具生理性。我们的数据显示，在5 Hz，250 Hz和2000 Hz的正弦波电流刺激可能不能用作膀胱充盈感的半客观测量，因为CPT与膀胱充盈感之间没有相关性。

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