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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Synaptosomal and brain slice cerebrocortical (3H)L-glutamate uptake in a rat model of chronic hepatic encephalopathy.
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Synaptosomal and brain slice cerebrocortical (3H)L-glutamate uptake in a rat model of chronic hepatic encephalopathy.

机译：慢性肝性脑病大鼠模型中的突触体和脑片脑皮质（3H）L-谷氨酸摄取。

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摘要

Cerebrocortical [3H]L-glutamate uptake was examined using brain slices and synaptosomes obtained from rats with portal vein and bile duct ligation. In addition, the effect of in vitro addition of 5 mM ammonia on glutamate uptake parameters was determined. There was no significant difference in brain slice or synaptosomal glutamate uptake in rats with portal vein and bile duct ligation compared to control rats. In vitro addition of ammonia had no effect on uptake kinetics in either brain slices or synaptosomes. These results suggest that glutamate uptake kinetics are not perturbed in this animal model of chronic hepatic encephalopathy.
机译：使用脑切片和门静脉和胆管结扎大鼠获得的突触体检查脑皮质[3H] L-谷氨酸的摄取。此外，确定了体外添加5 mM氨水对谷氨酸吸收参数的影响。与对照组相比，门静脉和胆管结扎的大鼠的脑切片或突触体谷氨酸摄取没有显着差异。体外添加氨对脑切片或突触小体的摄取动力学没有影响。这些结果表明，在这种慢性肝性脑病动物模型中，谷氨酸的摄取动力学不受干扰。

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