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A unifying hypothesis for acetylcholine release.

机译:乙酰胆碱释放的统一假设。

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摘要

Mediatophore is the only nerve terminal membrane protein known to translocate acetylcholine upon calcium action. It is localized at the active zone. In this review we attempted to describe its role in relation to the vesicular and membrane protein complexes that are formed at the active zone. The model pictures a possible set of sequential steps that lead to exocytosis. The smallest quantal events are attributed to mediatophore opening momentarily, while synaptic vesicles synchronize release by controlling the calcium microdomain. A clear distinction is made between sub-quantal ACh release preserved after Botulinum toxin action, and exocytosis of vesicular contents. A cybernetic model for release and exocytosis related to protein interactions is presented for future works.
机译:中间体细胞是已知在钙作用下能使乙酰胆碱转移的唯一神经末梢膜蛋白。它位于活动区域。在这篇综述中,我们试图描述其与在活性区形成的囊泡和膜蛋白复合物有关的作用。该模型描绘了可能导致胞吐作用的一系列连续步骤。最小的定量事件归因于中视团瞬间打开,而突触小泡通过控制钙微区来同步释放。肉毒杆菌毒素作用后保留的亚量ACh释放与囊泡内容物的胞吐作用之间存在明显的区别。提出了与蛋白质相互作用有关的释放和胞吐作用的控制论模型,供以后的工作使用。

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