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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Activated microglia are the principal glial source of thromboxane in the central nervous system.
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Activated microglia are the principal glial source of thromboxane in the central nervous system.

机译：活化的小胶质细胞是中枢神经系统血栓烷的主要神经胶质来源。

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摘要

Thromboxane A2(TxA2) is a potent vasoconstrictor associated with cerebrovascular disease and is thought to be synthesized within tissues of the brain. In order to determine the cellular sources of TxA2 in the central nervous system (CNS), we measured the release of the stable metabolite TxB2 in cultures of mixed or highly enriched populations of brain glia. Using techniques which isolated large numbers of highly enriched microglia and astroglia, we found that only microglia release TxB2. Moreover, microglia, not astroglia, contain the requisite synthetic enzyme thromboxane synthase. Phagocytic signals and lipopolysaccharide are potent stimulants of microglial release of thromboxane, with lesser effects shown by platelet activating factor and substance P. We conclude that microglia, when activated, are the principal source of brain-derived thromboxane and may help to control vascular flow at sites of acute CNS injury.
机译：血栓烷A2（TxA2）是与脑血管疾病相关的有效血管收缩剂，被认为是在脑组织内合成的。为了确定中枢神经系统（CNS）中TxA2的细胞来源，我们测量了混合或高度富集的脑胶质细胞培养物中稳定代谢产物TxB2的释放。使用分离大量高浓度小胶质细胞和星形胶质细胞的技术，我们发现只有小胶质细胞释放TxB2。而且，小胶质细胞而不是星形胶质细胞包含必需的合成酶血栓烷合酶。吞噬信号和脂多糖是血栓烷的小胶质细胞释放的有效刺激物，血小板活化因子和P物质显示的作用较小。我们得出结论，小胶质细胞在被活化后是脑源性血栓烷的主要来源，并可能有助于控制血管血流中枢神经系统急性损伤部位。

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