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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism.
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In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism.

机译：体内13C NMR研究区隔性脑碳水化合物的代谢。

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摘要

Localized 13C nuclear magnetic resonance (NMR) spectroscopy provides a unique window for studying cerebral carbohydrate metabolism through, e.g. the completely non-invasive measurement of cerebral glucose and glycogen metabolism. In addition, label incorporation into amino acid neurotransmitters such as glutamate (Glu), GABA and aspartate can be measured providing information on Krebs cycle flux and oxidative metabolism. Given the compartmentation of key enzymes such as pyruvate carboxylase and glutamine synthetase, the detection of label incorporation into glutamine indicated that neuronal and glial metabolism can be measured in vivo. The purpose of this paper is to provide a critical overview of these recent advances into measuring compartmentation of brain energy metabolism using localized in vivo 13C NMR spectroscopy. The studies reviewed herein showed that anaplerosis is significant in brain, as is oxidative ATP generation in glia and the rate of glial glutamine synthesis attributed to the replenishment of the neuronal Glu pool and that brain glycogen metabolism is slow under resting conditions. This new modality promises to provide a new investigative tool to study aspects of normal and diseased brain hitherto unaccessible, such as the interplay between glutamatergic action, glucose and glycogen metabolism during brain activation, and the derangements thereof in patients with hepatic encephalopathy, neurodegenerative diseases and diabetes.
机译：局部13 C核磁共振（NMR）光谱提供了一个独特的窗口，可以通过例如大脑葡萄糖和糖原代谢的完全非侵入式测量。此外，可以测量标记掺入氨基酸神经递质（例如谷氨酸（Glu），GABA和天冬氨酸）的能力，从而提供有关克雷布斯循环通量和氧化代谢的信息。考虑到关键酶（例如丙酮酸羧化酶和谷氨酰胺合成酶）的分隔，对掺入谷氨酰胺的标记的检测表明可以在体内测量神经元和神经胶质的代谢。本文的目的是提供有关使用局部体内13C NMR光谱法测量脑能量代谢区隔的最新进展的重要综述。本文审查的研究表明，脑中的动脉粥样硬化很明显，神经胶质中的氧化ATP生成以及神经胶质谷氨酰胺池的补充所引起的神经胶质谷氨酰胺合成速率也很高，并且在静止状态下脑糖原代谢缓慢。这种新的方法有望提供一个新的研究工具，以研究迄今无法进入的正常和患病的大脑方面，例如在脑激活过程中谷氨酸能作用，葡萄糖和糖原代谢之间的相互作用，以及肝性脑病，神经退行性疾病和糖尿病。

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