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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets.
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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets.

机译：阿尔茨海默氏病的Abeta毒性：球形低聚物（ADDL）作为新的疫苗和药物靶标。

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Over the past several years, experiments with synthetic amyloid-beta peptide (Abeta) and animal models have strongly suggested that pathogenesis of Alzheimer's disease (AD) involves soluble assemblies of Abeta peptides (Trends Neurosci. 24 (2001) 219). These soluble neurotoxins (known as ADDLs and protofibrils) seem likely to account for the imperfect correlation between insoluble fibrillar amyloid deposits and AD progression. Recent experiments have detected the presence of ADDLs in AD-afflicted brain tissue and in transgenic-mice models of AD. The presence of high affinity ADDL binding proteins in hippocampus and frontal cortex but not cerebellum parallels the regional specificity of AD pathology and suggests involvement of a toxin receptor-mediated mechanism. The properties of ADDLs and their presence in AD-afflicted brain are consistent with their putative role even in the earliest stages of AD, including forms of mild cognitive impairment.
机译：在过去的几年中，使用合成的淀粉样β肽（Abeta）和动物模型进行的实验强烈表明，阿尔茨海默氏病（AD）的发病机制涉及Abeta肽的可溶性组装（Trends Neurosci。24（2001）219）。这些可溶性神经毒素（称为ADDL和原纤维）似乎可能解释了不溶性纤维状淀粉样蛋白沉积与AD进展之间的不完美关联。最近的实验已经在患有AD的脑组织和AD的转基因小鼠模型中检测到ADDL的存在。在海马和额叶皮层而不是小脑中存在高亲和力ADDL结合蛋白，这与AD病理学的区域特异性相平行，并暗示了毒素受体介导的机制的参与。 ADDLs的性质及其在AD患病大脑中的存在与其在假定的早期阶段（包括轻度认知障碍的形式）中的假定作用相一致。

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