Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.

Baslow MorrisH

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.

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Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.

机译：有证据支持N-乙酰基-L-天冬氨酸作为分子水泵在中枢神经系统的有髓神经元中的作用。分析性审查。

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Molecular water pumps (MWPs) are characterized as biochemical systems existing at a compartmental boundary of living cells that can actively pump water against its gradient. A role for the observed intercompartmental transport of N-acetyl-L-aspartate (NAA), between neurons and oligodendrocytes in the CNS, as an efflux MWP for the removal of neuronal metabolic water has been proposed. In this review, accumulating evidence in support of such a role for NAA is presented, and the dynamics of the NAA cycle in myelinated neurons are considered. Based on the results of recent investigations, it is calculated that 1 mol of NAA is synthesized for every 40 mol of glucose (Glc) equivalent oxidized in the brain, and each mol of NAA may transport 121 mol of metabolic water out of neurons. In addition, turnover of total brain NAA is very rapid and appears to be only 16.7 h. Thus, the most important characteristic of NAA in the brain may not be its static level, but a dynamic aspect related to its rapid turnover. The relationship of NAA as a potential MWP to Canavan disease (CD), a genetic spongiform leukodystrophy in which the catabolic portion of the NAA cycle is deficient, and in a newly recognized brain disorder, hypoacetylaspartia, where the anabolic portion of the NAA cycle appears to be deficient, are discussed.

机译：分子水泵（MWP）的特征是存在于活细胞区室边界的生化系统，可以主动泵送水以对抗其梯度。已经提出了在CNS中的神经元和少突胶质细胞之间观察到的N-乙酰基-L-天冬氨酸（NAA）的室间运输的作用，作为用于去除神经元代谢水的外流MWP。在这篇综述中，提出了支持NAA如此作用的积累证据，并考虑了有髓神经元中NAA循环的动力学。根据最近的研究结果，可以计算出每40摩尔脑中氧化的葡萄糖（Glc）当量合成1摩尔的NAA，每摩尔的NAA可以将121摩尔的代谢水运出神经元。此外，全脑NAA的周转非常迅速，似乎只有16.7小时。因此，NAA在大脑中的最重要特征可能不是其静态水平，而是与其快速周转有关的动态方面。 NAA作为潜在的MWP与Canavan病（CD）的关系，Canavan病是一种遗传性海绵状白细胞营养不良，其中NAA循环的分解代谢部分不足，而在新认识到的脑疾患中，乙酰乙酰天冬氨酸不足，其中出现了NAA循环的合成代谢部分。不足之处，进行了讨论。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2002年第4期|共6页
作者
Baslow MorrisH;
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正文语种 eng
中图分类生物化学;
关键词
Aquaporins; Aspartic Acid; Body Water; Brain; Nerve Fibers; Myelinated; Nerve Tissue Proteins; 水孔蛋白类; 天冬氨酸; 身体水份; 脑; 神经纤维; 有髓鞘的; 神经组织蛋白质类;

机译：Aquaporins;Aspartic Acid;Body Water;Brain;Nerve Fibers;Myelinated;Nerve Tissue Proteins;水孔蛋白类;天冬氨酸;身体水份;脑;神经纤维;有髓鞘的;神经组织蛋白质类;

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1. Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. [J] . Baslow MorrisH Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2002,第4期

机译：有证据支持N-乙酰基-L-天冬氨酸作为分子水泵在中枢神经系统的有髓神经元中的作用。分析性审查。
2. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. [J] . Kitada K, Akimitsu T, Shigematsu Y, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2000,第6期

机译：N-乙酰基-L-天冬氨酸在震颤大鼠脑中的积累，该突变体在中枢神经系统中表现出缺失样癫痫发作和海绵状变性。
3. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. [J] . Geyer J, Fernandes CF, Doring B, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第4期

机译：孤儿载体蛋白Slc10a4的克隆和分子表征：在大鼠中枢神经系统胆碱能神经元中的表达。
4. Assessing the impact of auto-correlations on the information represented by neurons in the central nervous system. [D] . Scaglione, Alessandro. 2010

机译：评估自相关对中枢神经系统中神经元表示的信息的影响。
5. Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery. [O] . H K Yip, E M Johnson Jr 1984

机译：发育中的背根神经节神经元需要其中央过程提供营养支持：证据证明神经生长因子从中枢神经系统向周围逆行转运。
6. Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery. [O] . Yip, H K, Johnson, E M 1984

机译：发育中的背根神经节神经元需要其中央过程提供营养支持：证据证明神经生长因子从中枢神经系统向周围逆行转运。

Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.

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