Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat.

Papp H; Pakaski M; Kasa P

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat.

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Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat.

机译：Presenilin-1和淀粉样前体蛋白在成年大鼠的坐骨神经中双向运输。

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The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport of these proteins has been demonstrated in the sciatic nerve of adult rat. Double-ligation of the sciatic nerve for 6, 12 or 24h was observed to cause a progressive accumulation of the 45kDa presenilin-1 holoprotein and APPs with molecular masses of 116 and 94kDa on both sites of the ligature. It is concluded that the functions of presenilin-1 and APPs are not restricted to the neuronal perikarya: they may carry information in both directions, from the cell body to the axon terminals and vice versa.

机译：淀粉样前体蛋白（APP）和早老素-1（PS-1）不仅对各种神经元的正常功能很重要，而且在阿尔茨海默氏病（AD）的发病机理中也起着重要作用。通过使用免疫组织化学和蛋白质印迹技术，已经在成年大鼠的坐骨神经中证明了这些蛋白的双向轴突运输。坐骨神经的两次结扎持续6、12或24h会在结扎的两个位点上引起45kDa早老素1全蛋白和分子量分别为116和94kDa的APP的逐步积累。结论是presenilin-1和APP的功能并不局限于神经周围核：它们可能在两个方向上携带信息，从细胞体到轴突末端，反之亦然。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2002年第6期|共1页
作者
Papp H; Pakaski M; Kasa P;
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正文语种 eng
中图分类生物化学;
关键词
Sciatic Nerve; PSNL1 gene product; Amyloid beta-Protein Precursor; Adult; 坐骨神经; 淀粉样β蛋白前体; 成年人;

机译：Sciatic Nerve;PSNL1 gene product;Amyloid beta-Protein Precursor;Adult;坐骨神经;淀粉样β蛋白前体;成年人;

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1. Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat. [J] . Papp H, Pakaski M, Kasa P Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2002,第6期

机译：Presenilin-1和淀粉样前体蛋白在成年大鼠的坐骨神经中双向运输。
2. Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. [J] . Kasa P, Papp H, Kovacs I, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第1a2期

机译：体内应用的人淀粉样蛋白β1-42抑制了大鼠坐骨神经中蛋白质的快速轴突运输。
3. Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat. [J] . Fakla I, Kovacs I, Yamaguchi H, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2000,第2期

机译：淀粉样前体蛋白，突触素和早老素-1在大鼠发育中小脑的不同区域中的表达。
4. Proteomic Imaging of amyloids in Brains from Amyloid Precursor Protein (APP) Transgenic Mice in comparison with Human Alzheimer Amyloid [C] . Masaya Ikegawa, Tomohiro Miyasaka, Noriyuki Iwasaki, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：淀粉样蛋白前体蛋白（APP）转基团的淀粉样蛋白淀粉样蛋白蛋白质组学成像与人阿尔茨海默蛋白相比
5. The minimum effective dose of lidocaine needed to block evoked potentials in the sciatic nerve of the rat. [D] . Stelflug, Bradley Wayne. 1998

机译：阻断大鼠坐骨神经诱发电位所需的最小利多卡因有效剂量。
6. Axonal Transport of Microtubule-Associated Protein 1B (MAP1B) in the Sciatic Nerve of Adult Rat: Distinct Transport Rates of Different Isoforms [O] . Dongling Ma, B. Timothy Himes, Thomas B. Shea, 2000

机译：成年大鼠坐骨神经中微管相关蛋白1B（MAP1B）的轴突运输：不同亚型的不同运输率。
7. Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of β-Amyloid Precursor Protein in the Optic Nerve [O] . Anil Amaratunga, Richard E. Fine 1995

机译：在视神经中β-淀粉样蛋白前体蛋白的快速轴突转换期间产生淀粉样蛋白C-末端片段
8. Regeneration of Motor Axons in the Rat Sciatic Nerve Studied by Labeling with Axonally Transported Radioactive Proteins [R] . Forman, D. S., Berenberg, R. A. 1978

机译：用轴突运输放射性蛋白标记研究大鼠坐骨神经运动轴突的再生

Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat.

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